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MetabolomicsEffects of Zinc on GI tract metabolites (Part 1: Esophagus)
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ORGANISM(S): Mus musculus 
ST000330 | MetabolomicsWorkbench
Transcriptomicsgene expression profiles of Barrett's esophagus, squamous esophagus and gastric cardia
SAGE performed on biopsies of Barrett's esophagus, squamous esophagus and gastric cardia taken from a metaplastic Barrett's esophagus patient. Keywords: SAGE comparative analysis of gene expression profiles of Barrett's esophagus, normal squamous esophagus and gastric cardia tissue
ORGANISM(S): Homo sapiens 
2005-06-20 | E-GEOD-2769 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome profiling of Esophageal adenocarcinoma and Barrett's
RNA-seq was performed on esophageal adenocarcinoma (EAC), Barrett's without dysplasia, Barrett's with low-grade dysplasia (LGD) and normal squamous esophagus tissue to find early alterations in the transcriptome level turning Barrett's dysplastic.
ORGANISM(S): Homo sapiens 
2017-07-23 | E-MTAB-4054 | biostudies-arrayexpress
TranscriptomicsProfiling of circulating microRNAs in patients with Barrettâ??s esophagus and esophageal adenocarcinoma
miRNAs were extracted from plasma samples of healthy volunteers, patients with Barrettâ??s esophagus and patients with esophageal adenocarcinoma. We used the Serum / Plasma Focus miRNA PCR panel (Exiqon, Denmark) to quantitate miRNA presence in the different patient groups. PCR miRNA profiling. miRN...
ORGANISM(S): Homo sapiens 
2015-11-19 | E-GEOD-51410 | biostudies-arrayexpress
TranscriptomicsProcessed small RNA sequencing data of healthy and disease tissue samples from patients with esophageal adenocarcinoma or precursor lesions
In the past decades, the incidence of esophageal adenocarcinoma has increased dramatically in Western populations. Better understanding of disease etiology along with the identification of novel prognostic and predictive biomarkers are urgently needed to improve the dismal survival probabilities. He...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-10003 | biostudies-arrayexpress
TranscriptomicsWhole genome expression array profiling highlights differences in mucosal defense genes in Barrett's esophagus and esophageal adenocarcinoma.
Esophageal adenocarcinoma (EAC) has become a major concern in Western countries due to rapid rises in incidence coupled with very poor survival rates. One of the key risk factors for the development of this cancer is the presence of Barrett’s esophagus (BE), which is believed to form in response to ...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-28302 | biostudies-arrayexpress
TranscriptomicsmiR-223 in esophageal adenocarcinoma carcinogenesis
miR-223 is step-wise increasingly up-regulated in the normal esophagus - Barrett's esophagus -esophageal adenocarcinoma carcinoma sequence. In this study, we aimed to determine the function of miR-223 in esophageal adenocarcinoma carcinogenesis. miR-223 was transfected in OE33 cells using 10nM pre-m...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-44120 | biostudies-arrayexpress
ProteomicsPathology-driven epithelial sulfide loss reprograms the redox proteome and triggers Barrett’s esophagus
Background & AimsBarrett’s esophagus (BE), a metaplastic transformation driven by gastroesophageal reflux disease (GERD), induces oxidative stress but the underlying redox mechanisms remain poorly understood. Protein persulfidation (PSSH), a redox-sensitive, reversible, and antioxidative post-transl...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD047338 | Pride
Persulfidation  hydrogen sulfide  barrett’s esophagus  gastroesophageal reflux disease (gerd)  prostaglandin e2/interleukin 1/mtor cross-talk 
TranscriptomicsBarrett's esophagus
Barrett's esophagus transcriptome was analysed and compared with Barrett's esophagus primary cell culture and esophageal adenocarcinoma. Keywords: SAGE analysis to compare tissues Barrett's esophagus biopsy was taken from 1 male metaplastic Barrett's esophagus patient. Barrett's esophagus primary ce...
ORGANISM(S): Homo sapiens 
2006-06-28 | E-GEOD-5155 | biostudies-arrayexpress
ProteomicsGlobal Phospho-Proteomic Profiling of Pathway-Level Molecular Alterations in Barrett’s Esophagus
In the present study, we applied deep, quantitative mass-spectrometry to clinical samples (Barrett’s esophagus and matched adjacent normal biopsies) to gain a mechanistic understanding of the molecular pathways associated with disease progression. From our rich LC/MS profiles, we identified a robust...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD023293 | Pride
Biopsy  systems biology  mass spectrometry  disease signature 
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