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TranscriptomicsExpression from early pre-hematopoietic progenitors from mouse embryo
Hematopoietic Stem Cells (HSC) are originated during embryonic development from endothelial-like cells located in the ventral side of the dorsal aorta around day E10-12 of murine development. This region is called AGM for Aorta/Gonad/Mesonephros and refers to the tissues around the hemogenic aorta. ...
ORGANISM(S): Mus musculus 
2012-07-02 | E-GEOD-35395 | biostudies-arrayexpress
TranscriptomicsChIP-on-chip with anti-RBPj antibody from embryonic AGM E11.5
Hematopoietic Stem Cells (HSC) are originated during embryonic development from endothelial-like cells located in the ventral side of the dorsal aorta around day E10-12 of murine development. This region is called AGM for Aorta/Gonad/Mesonephros refering to the tissues around the hemogenic aorta. He...
ORGANISM(S): Mus musculus 
2014-10-22 | E-GEOD-52094 | biostudies-arrayexpress
TranscriptomicsGene expression from MCF7 breast cancer cells
Gene expression from MCF7 breast cancer cells at different times of TNFa incubation:pcs2 and 14-3-3 transduced cells Keywords: Expression Profiling by array We analyzed 2 arrays from each condition:MCF7-control tnf 0, MCF7-control tnf 20min, MCF-control tnf 90min, MCF7-14-3-3 tnf 0, MCF7-14-3-3 tnf...
ORGANISM(S): Homo sapiens 
2012-04-12 | E-GEOD-37139 | biostudies-arrayexpress
TranscriptomicsChromatin function of IkBa: ChIP-on-chip of IkBa
The Inhibitor of the NFkB, IkBa, is the main regulator of the NFkB pathway. Our data has demonstrated that there is an alternative function for IkBa in the chromatin that affects HOX and other developmental genes. Keywords: CHIP-chip Chip-on-chip analysis has demonstrated that IkBa associates to th...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-24011 | biostudies-arrayexpress
GenomicsIkBa associates with histone H2A in human keratinocytes
Here, we demonstrate that IkBa displays a predominant and unique nuclear localization in normal basal keratinocytes. This nuclear IkBa binds the chromatin through direct interaction of the ankyrin repeats with histone H2A and associates with the promoter and regulatory regions of several development...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-30082 | biostudies-arrayexpress
TranscriptomicsThe Notch/Hes1 pathway sustains NF-M-NM-:B activation through CYLD repression in T cell leukemia
The NF-M-NM-:B pathway is a critical regulator of the immune system and has been implicated in cellular transformation and tumorigenesis. NF-M-NM-:B response is regulated by the activation state of the IM-NM-:B kinase (IKK) complex and triggered by a wide spectrum of stimuli. We previously reported ...
ORGANISM(S): Homo sapiens 
2011-05-07 | E-GEOD-20667 | biostudies-arrayexpress
Transcriptomicsp27 binds to promoters of multiple genes leading to their repression
The role of the cyclin-cdk inhibitor p27 in tumorigenesis is still a controversial matter. We demonstrate here that p27 negatively regulates transcription of a number of genes (p27-target genes) involved in key cellular functions as RNA processing, translation, respiration and cell proliferation. Cr...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-20068 | biostudies-arrayexpress
TranscriptomicsExpression data from p27WT, p27CK and KO MEFs cells in quiescence
Low levels of the cell cycle regulator p27Kip1 are associated with a worse outcome in many tumor types. We report here a new regulatory role of p27Kip1 as a transcriptional regulator. In association with transcriptional factors such as ETS and E2F4 and co-repressors like p130, HDACs and mSin3A, p27 ...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-27672 | biostudies-arrayexpress
TranscriptomicsExpression data from p27delta51 MEFs cells in quiescence
Low levels of the cell cycle regulator p27Kip1 are associated with a worse outcome in many tumor types. We report here a new regulatory role of p27Kip1 as a transcriptional regulator. In association with transcriptional repressors such as p130, E2F4 and HDACs, p27 binds to promoters of multiple gene...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-20064 | biostudies-arrayexpress
UnknownLoss of humoral response 3 months after SARS-CoV-2 vaccination in the CKD spectrum: the multicentric SENCOVAC study.
Not available
S-EPMC9383183 | biostudies-literature
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