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ProteomicsThe pan-Sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line
The involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD017508 | Pride
Sirtuins Leukemia Human Mitochondria Orbitrap q-exactive 
TranscriptomicsTranscriptional effects of lentiviral vector-mediated PDK1 gene silencing in ovarian cancer xenografts
This experiment was designed to investigate the effect of PDK1 silencing on tumor growth, metabolism, and microenvironment modulation in vivo. Tumors were established in NOD/SCID mice by subcutaneous (s.c.) injection of an highly glycolytic ovarian cancer cell line (OVCAR3) transduced with lentivira...
ORGANISM(S): Homo sapiens 
2020-12-31 | E-MTAB-9877 | biostudies-arrayexpress
UnknownInhibition of Asparagine Synthetase Effectively Retards Polycystic Kidney Disease Progression
Not available
S-SCDT-10_1038-S44321-024-00071-9 | biostudies-other
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