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TranscriptomicsYeast expression data from conditions that inhibit sirtuins
Sir2 is an NAD+-dependent histone deacetylase, and is the founding member of a large, phylogentically conserved, family of such deacetylases called the Sirtuins. The budding yeast, Saccharomyces cerevisiae, harbors 4 paralogs of Sir2, known as Hst1, Hst2, Hst3, and Hst4. Reducing the intracellular N...
ORGANISM(S): Schizosaccharomyces pombe Saccharomyces cerevisiae 
2010-05-11 | GSE18488 | GEO
TranscriptomicsYeast expression data from conditions that inhibit sirtuins
Sir2 is an NAD+-dependent histone deacetylase, and is the founding member of a large, phylogentically conserved, family of such deacetylases called the Sirtuins. The budding yeast, Saccharomyces cerevisiae, harbors 4 paralogs of Sir2, known as Hst1, Hst2, Hst3, and Hst4. Reducing the intracellular N...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-10 | E-GEOD-18488 | biostudies-arrayexpress
UnknownSirtuins and Insulin Resistance.
Not available
S-EPMC6291425 | biostudies-literature
ProteomicsLithocholic acid targets TULP3-Sirtuins to deacetylate v-ATPase and activate AMPK
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-09-16 | PXD056134 |
TranscriptomicsSpecific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing
Expression profiling, ChiP-CHIP and phenotypic analysis were used to investigate the functional relationships of class III NAD+-dependent HDACs (Sirtuins) in fission yeast. We detected significant histone acetylation increases in Sirtuin mutants at their specific genomic binding targets and were thu...
ORGANISM(S): Schizosaccharomyces pombe 
2007-04-24 | GSE6114 | GEO
UnknownSirtuins: Sir2-related NAD-dependent protein deacetylases.
Not available
S-EPMC416462 | biostudies-literature
UnknownSirtuins in neurodegenerative diseases: a biological-chemical perspective.
Not available
S-EPMC3254029 | biostudies-literature
UnknownVirtual Screening in the Identification of Sirtuins' Activity Modulators.
Not available
S-EPMC9457788 | biostudies-literature
UnknownThe roles of sirtuins in ferroptosis.
Not available
S-EPMC10157232 | biostudies-literature
UnknownPotential Modulation of Sirtuins by Oxidative Stress.
Not available
S-EPMC4691645 | biostudies-literature
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