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TranscriptomicsTranscription profiling of human essential thrombocythemia JAK2V617F-negative from JAK2V617F-positive patients
In order to explore the gene expression signature in essential thrombocythemia (ET) patients in relation to JAK2V617F mutational status, expression profiling in circulating granulocytes was performed. Twenty ET were studied by microarray analysis and the results were confirmed by real-time quantitat...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-11003 | biostudies-arrayexpress
TranscriptomicsClass prediction models of thrombocytosis using genetic biomarkers
Using custom spotted oligonucelotide platelet-focused arrays, platelet samples were compared. 48 health controls, 23 reactive thrombocytosis (RT) and 24 essential thrombocythemia (ET) samples were compared. An 11-biomarker gene subset was identified that discriminated among the three cohorts with 86...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-12295 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of normal and JAK2V617F-positive erythroblasts of polycythemia vera and essential thrombocythemia
This experiment was designed to identify genes differentially expressed in association with the JAK2V617F mutation in polycythemia vera (PV) and essential thrombocythemia (ET). Peripheral blood was obtained from 20 ET and 16 PV patients and erythroid progenitors were grown in semi-solid methylcellul...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-MTAB-384 | biostudies-arrayexpress
TranscriptomicsChanges of miRNA expression in granulocytes of patients with polycythemia vera (PV) and essential thrombocythemia (ET) receiving INCB018424 in a Phase 2 study
A global microRNA expression profile was obtained from gradient-purified granulocytes (>95% pure) collected at the time of screening and at cycle 4 of treatment Protocol #18424-256 is a Phase 2 study of the JAK1 and JAK2 inhibitor INCB01842 in patients with advanced polycythemia vera (PV) and essent...
ORGANISM(S): Homo sapiens 
2012-09-26 | E-GEOD-32194 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human platelets from patients with essential thrombocythemia
Human blood platelets have important, regulatory functions in diverse hemostatic and pathological disorders, including vascular remodeling, inflammation, and wound repair. Microarray analysis was used to study the molecular basis of essential thrombocythemia, a myeloproliferative disorder with quant...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-2006 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human essential Thrombocythemia (ET) vs normal (baseline) megakaryocytes
Essential Thrombocythemia (ET) patients, as well as normal donors BM CD34+ cells were differentiated in thrombopoietin-treated liquid suspension cultures. Briefly, CD34+ cells (80,000 /mL) were resuspended in a serum-free medium in the presence of 100 ng/mL of human recombinant thrombopoietin (TPO; ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-567 | biostudies-arrayexpress
TranscriptomicsMicroarray of Human primary megakaryocyte from CALR mutated patient
CD34+ cells from 5 healthy donors versus 4 essential thrombocythemia patients with CALRm (2 with type 1 (del46 and del52) and 2 with type 2 (del13 and del19)) were in vitro cultured in SCF+TPO condition to enable megakaryocytic differentiation. MK were sorted and RNA were submitted to transcriptomic...
ORGANISM(S): Homo sapiens 
2020-07-01 | E-MTAB-9048 | biostudies-arrayexpress
TranscriptomicsJAK2V617F mutation in CD34+ stem cells of essential thrombocythemia
The JAK2V617F mutation has been reported in about 40-60% of Essential Thrombocythemia (ET) patients. However, little is known about specific molecular abnormalities of the hematopoietic stem cell compartment of ET according to JAK2 mutation. Therefore, we compared the gene expression profiles of bon...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-9827 | biostudies-arrayexpress
GenomicsEGAS00001000102-sc-20120222 - samples
Essential Thrombocythemia Myeloproliferative Disease exome sequencing
EGAD00001000129 | EGA
ProteomicsInvestigating the proteome of red blood cells and reticulocytes in Polycythemia Vera and Essential Thrombocythemia
The project aims at comparing the effect of the JAK2V617F mutation on protein expression in human erythroid cells in the context of Polycythemia Vera and Essential Thrombocythemia
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029965 | Pride
Reticulocytes Human red blood cells Erythrocytes Polycythemia vera Nlc-ms/ms Orbitrap fusion Essential thrombocythemia Jak2v617f 
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