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ProteomicsNuclear Estrogen Receptor alpha (ERα) interactome following estrogen and antiestrogen treatment.
The Estrogen Receptor alpha (ERα) controls key cellular functions in hormone responsive breast cancer by assembling in large functional multiprotein complexes. ERα ligands are classified as agonists and antagonist, according to the response they elicit, thus the molecular characterization of the of ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-02 | PXD018709 | Pride
Estrogen and antiestrogen signaling Interaction proteomics Estrogen receptor alpha (erα) 
TranscriptomicsTranscription profiling of human breat cancer cell lines reveals XBP1 confers estrogen independence and antiestrogen resistance
Human X-box binding protein-1 (XBP1) is an alternatively spliced transcription factor that participates in the unfolded protein response (UPR), a stress signaling pathway that allows cells to survive the accumulation of unfolded proteins in the endoplasmic reticulum lumen. We have previously demons...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8562 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human age-dichotomized ER+, N0 breast tumors reveals enhanced NF kappa B and AP-1 activity associated with antiestrogen resistant breast caner
Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. In this study, biomarkers co-ordinately up-regulated by NFKB and AP-1 with prognositic si...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7378 | biostudies-arrayexpress
TranscriptomicsExpression data from MCF-7 cells transfected with miR-26a and treated or not with estradiol
Altered expression of microRNAs (miRNAs), an abundant class of small non-protein-coding RNAs that mostly function as negative regulators of protein-coding gene expression, is common in cancer. Here we analyze the regulation of miRNA expression in response to estrogen, a steroid hormone that is invol...
ORGANISM(S): Homo sapiens 
2009-08-04 | E-GEOD-17460 | biostudies-arrayexpress
TranscriptomicsGenomics of signalling crosstalk of estrogen receptor alpha in breast cancer cells
The estrogen receptor a (ERa) is a ligand-regulated transcription factor. However, a wide variety of other extracellular signals can activate ERa in the absence of estrogen. The impact of these alternate modes of activation on gene expression profiles has not been characterized. We show that estroge...
ORGANISM(S): Homo sapiens 
2008-05-22 | E-GEOD-10466 | biostudies-arrayexpress
TranscriptomicsBreast cancer cells resistant to hormone deprivation maintain an estrogen receptor alpha-dependent, E2F-directed transcriptional program
A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. To model resistance to aromatase inhibitor (AI) therapy, long-term estrogen-deprived (LTED) derivatives of MCF-7 and HCC-1428 cells were generated through culture for 3 and 7 months under hormone...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-22533 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF-7 cells treated with Fulvestrant (ICI 182,780) and vehicle reveals origins and phenotypic variations of antiestrogen resistance in breast cancer
Expression profiles of MCF-7 cells treated with Fulvestrant (ICI 182,780) and vehicle Experiment Overall Design: MCF7 cells were grown in DMEM supplemented with 5% FCS (Hyclone, "Defined" grade). Growth medium was changed immediately before addition of 100 nM of ICI 182,780 or vehicle alone (0.1% et...
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-14986 | biostudies-arrayexpress
TranscriptomicsXBP1 confers estrogen independence and antiestrogen resistance in breast cancer cell lines
Human X-box binding protein-1 (XBP1) is an alternatively spliced transcription factor that participates in the unfolded protein response (UPR), a stress signaling pathway that allows cells to survive the accumulation of unfolded proteins in the endoplasmic reticulum lumen. We have previously demonst...
ORGANISM(S): Homo sapiens 
2007-08-13 | GSE8562 | GEO
UnknownAssociation of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance.
Not available
S-EPMC4036165 | biostudies-literature
UnknownInhibition of Tumor Microenvironment Cytokine Signaling Sensitizes Ovarian Cancer Cells to Antiestrogen Therapy.
Not available
S-EPMC9564160 | biostudies-literature
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