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TranscriptomicsWnt addiction of genetically defined cancers reversed by PORCN inhibition
Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. Inhibition of Wnt secretion by blocking an essential post-translational modification, palmitoleation, provides a useful therapeutic intervention. Inh...
ORGANISM(S): Homo sapiens 
2015-08-12 | E-GEOD-69687 | biostudies-arrayexpress
GenomicsMyc regulation of ETC Biogenesis and mtDNA Replication
Myc regulation of ETC Biogenesis and mtDNA Replication
PRJNA524122 | ENA
GenomicsNanostring Cancer Immune Panel Pre and Post ETC-159
Nanostring Cancer Immune Panel Pre and Post ETC-159
PRJNA702774 | ENA
GenomicsNanorana delacouri, Hynobius maoershanensis, etc
Nanorana delacouri, Hynobius maoershanensis, etc Raw sequence reads
PRJNA342792 | ENA
ProteomicsPHF8 Demethylates YY1 to Regulate ETC Gene and mROS to Promote Cancer Cell Growth
High levels of mitochondrial reactive oxygen species (mROS) are linked to cancer development, which is tightly controlled by electron transport chain (ETC). Targeting ETC represents a promising way of curing cancers. However, the epigenetic mechanisms governing ETC gene transcription to drive mROS p...
ORGANISM(S): Homo Sapiens 
PXD034400 |
TranscriptomicsMyc regulation of ETC Biogenesis and mtDNA Replication
To investigate the important role of Myc in regulating mitochondrial respiration and DNA biogenesis during Drosophila oogenesis, we dissected ovaries with developmental stages from germarium to stage 10 egg chambers from 4-6 day-old w1118 and mycP0/P0 mutant flies. We purified and compared mRNA tran...
ORGANISM(S): Drosophila melanogaster 
2019-09-01 | GSE126997 | GEO
OtherNanostring Cancer Immune Panel Pre and Post ETC-159
Tumor specimen samples from the multi-site, international, phase I advanced solid tumor ETC-159 clinical trial (NCT02521844, A*STAR Research Entities, Singapore), were analyzed using the PanCancer IO panel
ORGANISM(S): Homo sapiens 
2021-02-19 | GSE167039 | GEO
GenomicsETC-501 is a Brain Penetrant MNK Kinase Inhibitor that Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy
ETC-501 is a Brain Penetrant MNK Kinase Inhibitor that Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy
PRJNA1178117 | ENA
UnknownIdentification of homocysteine-suppressive mitochondrial ETC complex genes and tissue expression profile - Novel hypothesis establishment.
Not available
S-EPMC6006524 | biostudies-literature
TranscriptomicsTranscriptomic profile of the homeodomain protein CEH-23 under mitochondrial ETC stress in C. elegans
Transcriptomic profile of the homeodomain protein CEH-23 under mitochondrial ETC stress in C. elegans by comparing gene expression profile between isp-1(qm150) vs. ceh-23(ms23);isp-1(qm150) mutants
ORGANISM(S): Caenorhabditis elegans 
2017-07-02 | GSE67754 | GEO
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