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MetabolomicsMechanism of Hepatotoxicity Induced by Ethanol Extract of Emilia sonchifolia (L.) DC Revealed by Proteomics and Metabolomics

Objective: Hepatotoxicity has been reported for Emilia sonchifolia (L.) DC (Emilia sonchifolia). The plant material is typically prepared using two extraction methods for practical application: water extraction and ethanol extraction. However, our previous research only investigated its wate...

2025-10-30 | MTBLS13237 | MetaboLights
TranscriptomicsFyn-dependent prefrontal cortex gene networks in acute ethanol sensitivity
Fyn kinase has been implicated in multiple behavioral responses to ethanol and in the regulation of myelin gene expression. Here we tested whether Fyn kinase modulated basal or ethanol-responsive expression of genes regulated by acute ethanol in brain regions of the mesolimbocortical dopamine pathwa...
ORGANISM(S): Mus musculus 
2014-08-31 | E-GEOD-49028 | biostudies-arrayexpress
MetabolomicsMung bean (Vigna radiata L.) ethanol extracts alleviate alcoholic liver injury with modulation of gut microbiota and spermidine elevation

The pathophysiology of alcoholic-associated liver disease (ALD) is multifaceted. Utilizing the gut-liver axis framework and integrated multi-omics approaches, this study systematically evaluated the therapeutic potential of mung bean (Vigna radiata L.) ethanol extracts (MBE) in ALD, and its...

2025-10-10 | MTBLS13109 | MetaboLights
TranscriptomicsExpression data from ethanol and saline exposed mice [mRNA]
Mouse models of Fetal Alcohol Spectrum Disorder can be used to assess molecular changes underlying the disorder. Neonatal ethanol exposure in mice can be used to model third trimester ethanol exposure in humans. Mice were injected with 2.5 g/kg twice on each of postnatal days 4 and 7. Mice were allo...
ORGANISM(S): Mus musculus 
2015-03-07 | E-GEOD-66644 | biostudies-arrayexpress
TranscriptomicsPostnatal Growth Restriction and Gene Expression Changes in a Mouse Model of Fetal Alcohol Syndrome (Liver)
Growth restriction, craniofacial dysmorphology and central nervous system defects are the main diagnostic features of fetal alcohol syndrome. Studies in humans and mice have reported that the growth restriction can be prenatal and/or postnatal, but the underlying mechanisms remain unknown. We recen...
ORGANISM(S): Mus musculus 
2010-09-30 | E-GEOD-23106 | biostudies-arrayexpress
TranscriptomicsPostnatal Growth Restriction and Gene Expression Changes in a Mouse Model of Fetal Alcohol Syndrome (Kidney)
Growth restriction, craniofacial dysmorphology and central nervous system defects are the main diagnostic features of fetal alcohol syndrome. Studies in humans and mice have reported that the growth restriction can be prenatal and/or postnatal, but the underlying mechanisms remain unknown. We recen...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-23105 | biostudies-arrayexpress
TranscriptomicsEthanol-response genes and their regulation
The nematode shows responses to acute ethanol exposure that are similar to those observed in humans, mice, and Drosophila, namely hyperactivity followed by uncoordination and sedation. We used in this report the nematode Caenorhabditis elegans as a model system to identify and characterize the genes...
ORGANISM(S): Caenorhabditis elegans 
2005-12-02 | E-GEOD-3727 | biostudies-arrayexpress
TranscriptomicsChronic ethanol exposure results in time and brain-region dependent changes in gene coexpression networks.
We examined global gene expression profiles in amygdala (AMY), nucleus accumbens (NAC), prefrontal cortex (PFC) and Liver of male C57BL/6J mice exposed to 4 cycles of chronic intermittent ethanol (CIE) vapor. Animals were sacrificed at 0, 8, and 120 hr following the last ethanol exposure. Mice were ...
ORGANISM(S): Mus musculus 
2015-05-26 | E-GEOD-60676 | biostudies-arrayexpress
Transcriptomicsbrain expression data from adult mice prenatally exposed to ethanol
Moderate alcohol consumption during pregnancy can result in a heterogeneous range of neurobehavioural and cognitive effects, termed fetal alcohol spectrum disorders (FASD). We have developed a mouse moder of FASD that involves moderate ethanol exposure throughout gestation achieved by voluntary mat...
ORGANISM(S): Mus musculus 
2011-12-10 | E-GEOD-34305 | biostudies-arrayexpress
TranscriptomicsGenomic Analysis of Individual Differences in Ethanol Drinking: Evidence for Non-genetic Factors in C57BL/6 Mice
Here, we identify persistent and substantial variation in ethanol drinking behavior within an inbred mouse strain and utilize this model to identify gene networks influencing such non-genetic variation in ethanol intake. C57BL/6NCrl mice showed persistent inter-individual variation of ethanol intake...
ORGANISM(S): Mus musculus 
2011-03-01 | E-GEOD-26506 | biostudies-arrayexpress
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