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MetabolomicsMechanism of Hepatotoxicity Induced by Ethanol Extract of Emilia sonchifolia (L.) DC Revealed by Proteomics and Metabolomics

Objective: Hepatotoxicity has been reported for Emilia sonchifolia (L.) DC (Emilia sonchifolia). The plant material is typically prepared using two extraction methods for practical application: water extraction and ethanol extraction. However, our previous research only investigated its wate...

2025-10-30 | MTBLS13237 | MetaboLights
MetabolomicsMolecular Docking and Dynamic Study of Ethanol Extract of Citrus sinensis as Keap-1 and NMDA inhibitor in Brain Injury

Traumatic brain injury is a significant cause of mortality in young adults and disability in all age groups. Secondary injury involving various processes such as oxidative stress, which induced neuronal apoptosis, ensued afterward. This study aimed to analyze the active compounds of Citrus sinens...

2023-01-02 | MTBLS5785 | MetaboLights
TranscriptomicsFyn-dependent prefrontal cortex gene networks in acute ethanol sensitivity
Fyn kinase has been implicated in multiple behavioral responses to ethanol and in the regulation of myelin gene expression. Here we tested whether Fyn kinase modulated basal or ethanol-responsive expression of genes regulated by acute ethanol in brain regions of the mesolimbocortical dopamine pathwa...
ORGANISM(S): Mus musculus 
2014-08-31 | E-GEOD-49028 | biostudies-arrayexpress
TranscriptomicsEthanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.
Compared gene expression in lymphoblasoid cell lines from alcholics and controls and 24 hr treatment with ethanol. To elucidate the effects of a controlled exposure to ethanol on gene expression, we studied lymphoblastoid cell lines (LCLs) from 21 alcoholics and 21 controls. We cultured each cell li...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-52553 | biostudies-arrayexpress
MetabolomicsMung bean (Vigna radiata L.) ethanol extracts alleviate alcoholic liver injury with modulation of gut microbiota and spermidine elevation

The pathophysiology of alcoholic-associated liver disease (ALD) is multifaceted. Utilizing the gut-liver axis framework and integrated multi-omics approaches, this study systematically evaluated the therapeutic potential of mung bean (Vigna radiata L.) ethanol extracts (MBE) in ALD, and its...

2025-10-10 | MTBLS13109 | MetaboLights
TranscriptomicsComparison of the transcriptional response to ethanol in laboratory and wild yeast strains
An S288c-derived lab strain of Saccharomyces cerevisiae has lower ethanol resistance than either the vineyard strain M22 or the oak strain YPS163. We performed a 60 minute time-course experiment in the presence of 5% ethanol and compared the transcriptional response to ethanol between strains. We ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-17 | E-GEOD-22904 | biostudies-arrayexpress
TranscriptomicsCorrecting Direct Effects of Ethanol on Translation and Transcription Machinery Confers Ethanol Tolerance in Bacteria [Terminator_Readthrough_RNAseq]
The molecular mechanisms of ethanol toxicity and tolerance in bacteria, while important for biotechnology and bioenergy applications, remain incompletely understood. Genetic studies have identified potential cellular targets for ethanol and revealed multiple mechanisms of tolerance, but it remains d...
ORGANISM(S): Escherichia coli 
2014-06-18 | E-GEOD-56407 | biostudies-arrayexpress
TranscriptomicseQTL Mapping of the Yeast Ethanol Response
In a previous study, we identified extensive natural variation in the response to acute ethanol treatment in three yeast strains: a lab strain derived from the commonly used S288c (DBY8268), vineyard isolate M22, and oak soil strain YPS163. Many expression differences persisted across several module...
ORGANISM(S): Saccharomyces cerevisiae 
2014-10-02 | E-GEOD-54196 | biostudies-arrayexpress
TranscriptomicsExpression Differences in Ethanol Stress Response Between Saccharomyces cerevisiae Parent W303-1A Strain and its Two Ethanol Tolerant Mutants
Saccharomyces spp. are widely used for ethanol production however fermentation productivity is negatively affected by the impact of ethanol accumulation on yeast metabolic rate and viability. This study used microarray and statistical two-way ANOVA analysis to compare and evaluate gene expression pr...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-01 | E-GEOD-21120 | biostudies-arrayexpress
TranscriptomicsSystems Biology Analysis of Zymomonas mobilis ZM4 Ethanol Stress Responses
Background Zymomonas mobilis ZM4 is a capable ethanologenic bacterium with high ethanol productivity and ethanol tolerance. Previous studies indicated that several stress-related proteins and changes in the ZM4 membrane lipid composition may contribute to ethanol tolerance. However, the molecular m...
ORGANISM(S): Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821 
2013-09-04 | E-GEOD-21165 | biostudies-arrayexpress
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