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ProteomicsQuantitative Proteomics Reveals Metabolic Reprogramming during ETHE1 Deficiency, Part 2
Deficiency of mitochondrial sulfur dioxygenase (ETHE1) causes the severe metabolic disorder ethylmalonic encephalopathy, which is characterized by early-onset encephalopathy and defective cytochrome C oxidase because of hydrogen sulfide accumulation. Although the severe systemic consequences of the ...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-11 | PXD002742 | Pride
Metabolism Persulfide dioxygenase Acetylation Sulfide Liver Mouse Ethe1 Itraq Lc-ms/ms 
ProteomicsQuantitative Proteomics Reveals Metabolic Reprogramming during ETHE1 Deficiency, Part 1
Deficiency of mitochondrial sulfur dioxygenase (ETHE1) causes the severe metabolic disorder ethylmalonic encephalopathy, which is characterized by early-onset encephalopathy and defective cytochrome C oxidase because of hydrogen sulfide accumulation. Although the severe systemic consequences of the ...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-11 | PXD002741 | Pride
Metabolism Persulfide dioxygenase Acetylation Sulfide Liver Mouse Ethe1 Itraq Lc-ms/ms 
ProteomicsLC-MS/MS proteomics of ETHE1 deficient patient fibroblasts_Study-1
The mitochondrial enzyme ETHE1 is a persulfide dioxygenase essential for cellular sulfide detoxification, and its deficiency causes the severe and complex inherited metabolic disorder ethylmalonic encephalopathy (EE). In spite of well-described clinical symptoms of the disease, detailed cellular and...
ORGANISM(S): Homo sapiens (Human) 
2018-11-07 | PXD009880 | Pride
Patient fibroblasts Ethe1 deficiency Tmt labeling Lc-ms/ms ethylmalonic acid encephalopathy 
UnknownETHE1 mutations are specific to ethylmalonic encephalopathy.
Not available
S-EPMC2563233 | biostudies-literature
UnknownETHE1 Accelerates Triple-Negative Breast Cancer Metastasis by Activating GCN2/eIF2α/ATF4 Signaling.
Not available
S-EPMC10572406 | biostudies-literature
UnknownETHE1 dampens colorectal cancer angiogenesis by promoting TC45 Dephosphorylation of STAT3 to inhibit VEGF-A expression.
Not available
S-EPMC11358511 | biostudies-literature
UnknownETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer.
Not available
S-EPMC6592291 | biostudies-literature
UnknownEthylmalonic encephalopathy: Clinical course and therapy response in an uncommon mild case with a severe ETHE1 mutation.
Not available
S-EPMC7476058 | biostudies-literature
UnknownETHE1 and MOCS1 deficiencies: Disruption of mitochondrial bioenergetics, dynamics, redox homeostasis and endoplasmic reticulum-mitochondria crosstalk in patient fibroblasts.
Not available
S-EPMC6718683 | biostudies-literature
UnknownCharacterization of patient mutations in human persulfide dioxygenase (ETHE1) involved in H2S catabolism.
Not available
S-EPMC3531769 | biostudies-literature
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