ELK1 is a well-known target of the ERK branch (EGF-responsive) of the MAP kinase pathway. This transcription profiling experiment studied the effects of ELK1 depletion by siRNA and subsequent EGF stimulation.
Elk1 directs selective gene induction that is a substantial and critical component of growth signaling by AR in PC cells. Gene expression in LNCaP cells was determined in androgen-depleted medium in response to R1881 in ELK1 knock down (via AR shRNA) or in cells treated with control shRNA.
