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TranscriptomicsMicroarray analysis of splenic reservoir monocytes and their blood counterparts
A current paradigm states that monocytes circulate freely and patrol blood vessels, but differentiate irreversibly into dendritic cells or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The re...
ORGANISM(S): Mus musculus 
2009-08-02 | E-GEOD-14850 | biostudies-arrayexpress
TranscriptomicsMurine blood monocyte subsets
Monocytes and their lineage descendants serve as a central defense system against infection and injury but if uncontrolled can also promote an excessive pathological inflammatory response. Therefore a current research goal is to understand how the organism controls the number and function of monocyt...
ORGANISM(S): Mus musculus 
2012-04-05 | E-GEOD-32364 | biostudies-arrayexpress
TranscriptomicsInnate response activator B cells are sentinels that guard against polymicrobial sepsis
Innate immunity is fundamental to recognition and clearance of bacterial infection. The relevant cells and molecules that orchestrate an effective response, however, remain incompletely understood. Here we describe a previously unknown population of B cells, which we have named innate response activ...
ORGANISM(S): Mus musculus 
2012-02-07 | E-GEOD-32372 | biostudies-arrayexpress
TranscriptomicsRegulation of Monocyte Functional Heterogeneity by miR-146a
This SuperSeries is composed of the following subset Series: GSE32364: Murine blood monocyte subsets GSE32370: Regulation of monocyte functional heterogeneity by miR-146a Refer to individual Series
ORGANISM(S): Mus musculus 
2012-04-05 | E-GEOD-32392 | biostudies-arrayexpress
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