Eukaryotic aging

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DNBSEQ Eukaryotic Stranded Transcriptome library preparation- Stranded mRNA Library (1)
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- (1)
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CHEBI ID

CHEBI:16614 (1)
CHEBI:16613 (1)
CHEBI:16612 (1)
CHEBI:16611 (1)
CHEBI:17768 (1)
CHEBI:16615 (1)
CHEBI:17927 (1)
CHEBI:17148 (1)
CHEBI:16610 (1)

Metabolite Name

Spermidine M+05 (1)
Spermidine M+04 (1)
Spermidine M+03 (1)
Spermidine M+02 (1)
Spermidine M+01 (1)
Spermidine M+00 (1)
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N-Acetylspermidine M+05 (1)
N-Acetylspermidine M+04 (1)
N-Acetylspermidine M+03 (1)
N-Acetylspermidine M+02 (1)
N-Acetylspermidine M+01 (1)
N-Acetylspermidine M+00 (1)
N-Acetylputrescine M+05 (1)
N-Acetylputrescine M+04 (1)
N-Acetylputrescine M+03 (1)
N-Acetylputrescine M+02 (1)
N-Acetylputrescine M+01 (1)
N-Acetylputrescine M+00 (1)

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Transcription profiling by array (32)
RNA-seq of coding RNA (5)
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Lab affiliation

Aging $ Metabolism, Gene Translation Laboratory, Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain. (1)
Aging and Muscle Metabolism Lab, Department of Biomedical Sciences & Service of Endocrinology, Diabetes and Metabolism, Faculty of Biology and Medicine, Lausanne University Hospital and University of Lausanne, Bugnon 7, 1005 Lausanne, Switzerland (1)
Ben-Gurion University (1)
Departement of Molecular and Cell Biology, University of Geneva, Geneva, Switzerland (1)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (1)
Department of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea (1)
Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, Biomedicum, 171 65 Solna, Sweden Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden (1)
Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University (Third Military Medical University), Chongqing 400037, China (1)
Département de Biologie Cellulaire, Université de Genève (1)
Institute of Clinical Pharmacology, Goethe-University, Frankfurt am Main, Germany (1)
School of Life Sciences, Tsinghua University, China (1)
Sichuan Agricultural University (1)
Structural and Computational Biology Unit European Molecular Biology Laboratory Meyerhofstr. 1 69117 Heidelberg Germany (1)

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Nucleosome loss leads to global transcriptional upregulation and genomic instability during yeast replicative aging

All eukaryotic cells divide a finite number of times, termed replicative aging, but the reason for this is not clear. Consistent with the decreased total histone protein levels in aged Saccharomyces cerevisiae, which is a cause of aging (1), we find that nucleosome occupancy decreases 50% across the...

ORGANISM(S): Saccharomyces cerevisiae

2014-02-26 | E-GEOD-47023 | biostudies-arrayexpress

Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Colon data]

By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body i...

ORGANISM(S): Mus musculus

2012-09-03 | E-GEOD-39973 | biostudies-arrayexpress

Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Small Intestine data]

ORGANISM(S): Mus musculus

2012-09-03 | E-GEOD-39974 | biostudies-arrayexpress

Transcription profiling of mouse aging lung from two strains C57BL/6J and DBA/2J

We hypothesize that gene expression in the aging lungs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes.re specifically, (1) Aging DBA/2J mice compared to aging C57BL/6 mice are known to be accelerated in their lung physiology andrphometry; (2) C57BL/6...

ORGANISM(S): Mus musculus

2009-04-23 | E-GEOD-6591 | biostudies-arrayexpress

SIRT1 redistribution on chromatin promotes genome stability but alters gene expression during aging

This SuperSeries is composed of the following subset Series: GSE13075: SIRT1 and H1AcK26 promoter-association in mouse ES cells changes upon oxidative stress GSE13120: Age-related gene expression changes in mouse neocortex Refer to individual Series

ORGANISM(S): Mus musculus

2010-05-15 | E-GEOD-13121 | biostudies-arrayexpress

Transcription profiling of mouse neocortex to investigate age-related gene expression changes

Aging is associated with major nuclear changes affecting genomic integrity and gene expression. Here we compare the gene expression profiles in the neocortex of young (5 months old) and old (30 months old) B6xC3 F1 mice. In a related study, we compare genes that change expression with age to SIRT1 a...

ORGANISM(S): Mus musculus

2009-01-13 | E-GEOD-13120 | biostudies-arrayexpress

Chemically induced reprogramming to reverse cellular aging.

Not available

S-EPMC10373966 | biostudies-literature

Transcription profiling of prop-1 and Ghrhr mutations in gene expression during normal aging in mice (Ames dwarf and Little mice)

Effects of the prop-1 and Ghrhr mutations in gene expression during normal aging in mice.

ORGANISM(S): Mus musculus

2004-10-15 | E-MEXP-153 | biostudies-arrayexpress

An aging-independent replicative lifespan in a symmetrically dividing eukaryote.

Not available

S-EPMC5332158 | biostudies-literature

Multiple DNA repair pathways collectively protect against DNA damage-induced replicative aging.

We demonstrate that transcriptomic profiling of the NER mutant ercc-1 offers better understanding of the complex phenotypes of ercc-1 deficiency in C. elegans, as it does in mammalian models. There is a transcriptomic shift in ercc-1 mutants that suggests a stochastic impairment of growth and develo...

ORGANISM(S): Caenorhabditis elegans

2013-09-15 | E-GEOD-39145 | biostudies-arrayexpress

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