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MetabolomicsMembrane lipid as cofactor of cargo uptake and release by box-like lipid transfer proteins
Lipid transfer proteins (LTPs) shuttle their cargo lipids between cellular membranes. LTPs facilitate the costly extraction of a lipid from a donor membrane, and its delivery into the acceptor membrane, but the mechanisms remain poorly understood. We combined extensive molecular dynamics simulations...
2026-10-06 | MTBLS15933 | MetaboLights
MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
ProteomicsTurboID-EV: a proximity-labeling proteomic approach to dissect the uptake mechanism of extracellular vesicles
Extracellular vesicles (EVs), including exosomes, have been recognized as key mediators of intercellular communications through donor EV and recipient cell interaction. Until now, most studies have focused on the development of analytical tools to separate EVs and their applications for molecular p...
ORGANISM(S): Homo Sapiens (human) 
2023-08-21 | PXD040569 | JPOST Repository
MetabolomicsA comprehensive metabonomic and transcriptomic analysis reveals how inhibiting glycolysis affects regulatory T cell proliferation

Background: Blocking glycolysis inhibits regulatory T cells (Tregs), which are often hijacked by tumor cells whose survival relies on glycolysis to inhibit antitumor immunity. However, how glycolysis influences Treg proliferation/differentiation remains unclear. Monocarboxylate transporters (MCTs...

2024-08-06 | MTBLS8002 | MetaboLights
ProteomicsExtracellular vesicles from pancreatic cancer cells activate mast cells which in turn promote tumor cell proliferation and establish a tumor-supportive microenvironment
Background and aim: Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer progression. Driver genes directing EV function, the EV-recipient cells, as well as their cellular response to EV uptake remain, however, to be identified. To address th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-06 | MSV000093583 | MassIVE
UnknownDevelopment of a quantitative method to measure EV uptake.
Not available
S-EPMC6642168 | biostudies-literature
GenomicsCRIPTO regulates EV uptake and fibroblast activation in breast cancer [scRNAseq]
CRIPTO regulates EV uptake and fibroblast activation in breast cancer [scRNAseq]
PRJNA1094994 | ENA
ProteomicsMechanistic Insight into Human Milk Extracellular Vesicle-Intestinal Barrier Interactions
Human milk extracellular vesicles (EVs) are crucial mother-to-baby messengers that transfer biological signals. These EVs are reported to survive digestion and transport across the intestine. The mechanisms of interaction between human milk EVs and the intestinal mucosa, including epithelial uptake ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057096 | Pride
Ev intestinal translocation Ev cell uptake Human milk evs Ev proteomics 
TranscriptomicsProteomic signatures of extracellular vesicles secreted by non-mineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth
Beyond forming bone, osteoblasts play pivotal roles in various biological processes, including hematopoiesis and bone metastasis. Extracellular vesicles (EVs) have recently been implicated in intercellular communication via transfer of proteins and nucleic acids between cells. Here, we focused on th...
ORGANISM(S): Homo sapiens 
2014-10-28 | E-GEOD-56172 | biostudies-arrayexpress
GenomicsCRIPTO regulates EV uptake and fibroblast activation in breast cancer [Bulk RNAseq]
CRIPTO regulates EV uptake and fibroblast activation in breast cancer [Bulk RNAseq]
PRJNA1094991 | ENA
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