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The BMP signaling pathway regulates multiple steps of hematopoiesis, mediated through receptor-regulated Smads, including Smad1 and Smad5. Here we use loss-of-function approaches in zebrafish to compare the roles of Smad1 and Smad5 during embryonic hematopoiesis. Microarray experiments revealed that...
ORGANISM(S): Danio rerio 
primary ALL cells (B-lineage) resistant to prednisolone by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
Cellular drug resistance is associated with an unfavorable prognosis in pediatric acute lymphoblastic leukemia (ALL). To identify genes conferring resistance to antileukemic agents, we analyzed the expression of >12,700 genes in sensitive and resistant ALL cells obtained at diagnosis from 174 patien...
ORGANISM(S): Homo sapiens 
primary ALL cells (B-lineage) resistant to daunorubicin by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
primary ALL cells (B- and T-lineage) sensitive to vincristine by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
primary ALL cells (B-lineage) sensitive to daunorubicin by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
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