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TranscriptomicsGenome-wide profiling of gene expression of normal and Tbx20 knockout adult mouse whole heart
Tbx20 is a transcription factor important for heart development. To assess the role of Tbx20 in the adult heart, we generated a conditional knockout for this gene, specifically in cardiomyocytes. We profiled gene expression levels using RNA-seq in both normal and knockout adult mouse hearts to ident...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-30943 | biostudies-arrayexpress
GenomicsGenome-wide mapping of Tbx20 (GFP-tagged) in adult mouse whole heart
Tbx20 is a transcription factor important for heart development. To assess the role of Tbx20 in the adult heart, we sought to identify regulatory regions, gene targets and pathways regulated by this TF. To this end, we used chromatin immunoprecipitation (ChIP) of Tbx20 fused to GFP to locate binding...
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-29636 | biostudies-arrayexpress
TranscriptomicsExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
The Murphy Roth Large (MRL) mouse, a strain capable of regenerating right ventricular myocardium, has a high post-myocardial infarction (MI) survival rate compared with C57BL6/J (C57) mice. The biological processes responsible for this survival advantage are unknown. We compared acute post-MI gene e...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-19322 | biostudies-arrayexpress
GenomicsGenome-wide chromatin-immunoprecipitation studies of purified SAN cells reveals critical direct targets of ISL1 and suggests potential co-factor families for ISL1 action in SAN cells
Understanding factors that drive development and function of the sinoatrial node (SAN) is crucial to development of potential therapies for sinus arrhythmias, including potential generation of biological pacemakers. Here, we identify a key cell autonomous role for the LIM homeodomain transcription f...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-68974 | biostudies-arrayexpress
UnknownDietary outcomes within the study of novel approaches to weight gain prevention (SNAP) randomized controlled trial.
Not available
S-EPMC6357348 | biostudies-literature
UnknownBreast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2.
Not available
S-EPMC3387216 | biostudies-literature
UnknownPowerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies.
Not available
S-EPMC10084891 | biostudies-literature
UnknownA statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.
Not available
S-EPMC11981678 | biostudies-literature
UnknownWhole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.
Not available
S-EPMC8394596 | biostudies-literature
UnknownDynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.
Not available
S-EPMC7483769 | biostudies-literature
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