Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.

ABSTRACT:

Background

Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing.

Methods

The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an additional 13,257 individuals. We examined five complementary traits describing different aspects of sleep-disordered breathing: the apnea-hypopnea index, average oxyhemoglobin desaturation per event, average and minimum oxyhemoglobin saturation across the sleep episode, and the percentage of sleep with oxyhemoglobin sa

SUBMITTER: Cade BE 

PROVIDER: S-EPMC8394596 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature