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TranscriptomicsRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Recently, we defined four subtypes of pancreatic cancer that are associated with distinct histopathological characteristics and differential survival, namely, Squamous, Pancreatic Progenitor, Immunogenic, and ADEX (Bailey et al 2016, Nature). We also found that loss of CXCR2 was associated with a sw...
ORGANISM(S): Mus musculus 
2018-05-01 | E-MTAB-6620 | biostudies-arrayexpress
UnknownA phase 1/2a dose-finding study and biomarker assessment of oral lisavanbulin in patients with high-grade glioma or glioblastoma.
Not available
S-EPMC12208313 | biostudies-literature
ProteomicsProteomic analysis Carcinoma associated fibroblasts (CAFs) following genetic manipulation of NID2 expression
Proteomic anlaysis was performed on CAF GFP-1 KRAB, CAF B500 NID2 KRAB and CAF C500 NID2 KRAB cell lines
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050045 | Pride
Carcinoma associated fibroblasts Nid2 
ProteomicsTemporally-resolved proteomic profiling of mouse pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized by progressive matrix deposition and fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrix proteome (matrisome) of the highly-metastatic KPC and poorly-metastatic KPflC mouse...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD045830 | Pride
Cancer Pancreas Extracellular matrix 
UnknownTemporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response.
Not available
S-EPMC11221519 | biostudies-literature
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