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TranscriptomicsRNAi profiling of human Ewings sarcoma A673 Stable-Knockdown
A673 Ewing's sarcoma cells containing either control RNAi retroviral constructs (luc-RNAi), or RNAi retroviral constructs targeting the endogenous EWS/FLI fusion transcript (either EF-2-RNAi or EF-4-RNAi). Experiment Overall Design: Eight samples total. Four luc-RNAi, and four EWS/FLI knockdown con...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4560 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Ewing's sarcoma tumor samples and cell lines
Comparison of expression profiling from Ewing's sarcoma tumor specimen to Ewing's sarcoma cell lines
ORGANISM(S): Homo sapiens 
2008-03-26 | E-MEXP-1142 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Ewings sarcoma cell line A673 inducible-rescue experiment
A673 Ewing's sarcoma cells, with inducible EWS/FLI cDNA, harboring the EF-2-RNAi retrovirus, induced (or uninduced) for the indicated time period. Experiment Overall Design: Two replicates of a time course series, including the indicated time points, including both induced and uninduced samples.
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4563 | biostudies-arrayexpress
TranscriptomicsRUNX3 Facilitates Growth of Ewing Sarcoma Cells
Ewing sarcoma is an aggressive pediatric small round cell tumor that predominantly occurs in bone. Approximately 85% of Ewing sarcomas harbor the EWS/FLI fusion protein, which arises from a chromosomal translocation, t(11:22)(q24:q12). EWS/FLI interacts with numerous lineage-essential transcription...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-56900 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Ewing sarcoma (A673) cells treated with cytarabine, doxorubicin and puromycin oral tongue squamous cell carcinomas to identify novel potential prognosticators
An increasing number of cancer-associated mutations have been identified. Unfortunately, little therapy today exploits these tumor-specific genetic lesions. Often, the resulting oncoproteins have been intractable to easy manipulation with current small molecule screening approaches. To overcome this...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-6930 | biostudies-arrayexpress
TranscriptomicsshRNA profiling of human Ewings sarcoma samples to produce a molecular function map of Ewinga??s Sarcoma
EWS-FLI1 is a chimeric ETS transcription factor that is, due to a chromosomal rearrangement, specifically expressed in Ewing’s sarcoma family tumors (ESFT) and is thought to be the initiating event in the development of the disease. Previous genomic profiling experiments have identified a number o...
ORGANISM(S): Homo sapiens 
2009-05-11 | E-GEOD-14543 | biostudies-arrayexpress
TranscriptomicsA TARBP2-dependent miRNA expression profile determines cancer stem cell properties and provides new candidate therapeutic reagents in Ewing's sarcoma
This SuperSeries is composed of the following subset Series: GSE30513: MicroRNA expression profiling of Ewing sarcoma cancer stem cells GSE31144: MicroRNA expression profiling of Ewing sarcoma cell lines upon TARBP2 depletion GSE31145: MicroRNA expression profiling of Ewing sarcoma spheres vs. adher...
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-31146 | biostudies-arrayexpress
TranscriptomicsRNA-Seq profiling of Ewing's sarcoma and MSC cell lines
Comparison of expression profile of Ewing's sarcoma with cell of origin, mesenchymal stem cells with the goal of identifying novel therapeutic targets. 3 Ewing's cell lines compared to 2 MSC cell lines
ORGANISM(S): Homo sapiens 
2016-03-03 | E-GEOD-73610 | biostudies-arrayexpress
TranscriptomicsEwing's sarcoma tumor samples
This SuperSeries is composed of the following subset Series: GSE37370: microRNA expression data from Ewing's sarcoma tumor samples GSE37371: Expression data from Ewing's sarcoma tumor samples Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-06-11 | E-GEOD-37372 | biostudies-arrayexpress
ProteomicsQuantitative proteomics identifies ML111 as a cell-cycle inhibitor
We used quantitative mass spectrometry to analyze the effect of ML111 on the whole proteome of SK-N-MC cells. Results: ML111 treatment results in the accumulation of APC/C substrates suggesting that ML111 disrupts the cell cycle at or before the mitotic spindle assembly checkpoint.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-12-15 | MSV000086599 | MassIVE
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