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TranscriptomicsRUNX3 Facilitates Growth of Ewing Sarcoma Cells
Ewing sarcoma is an aggressive pediatric small round cell tumor that predominantly occurs in bone. Approximately 85% of Ewing sarcomas harbor the EWS/FLI fusion protein, which arises from a chromosomal translocation, t(11:22)(q24:q12). EWS/FLI interacts with numerous lineage-essential transcription...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-56900 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Ewing sarcoma (A673) cells treated with cytarabine, doxorubicin and puromycin oral tongue squamous cell carcinomas to identify novel potential prognosticators
An increasing number of cancer-associated mutations have been identified. Unfortunately, little therapy today exploits these tumor-specific genetic lesions. Often, the resulting oncoproteins have been intractable to easy manipulation with current small molecule screening approaches. To overcome this...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-6930 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Ewing sarcoma samples
Expression profiling of Ewing sarcoma samples in the frame of the CIT program from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Ewing sarcoma a rare pediatric tumor characterized by EWSR1-ETS fusions, is predominantly observed in populations of European ancestry. A geno...
ORGANISM(S): Homo sapiens 
2012-02-11 | E-GEOD-34620 | biostudies-arrayexpress
TranscriptomicsIdentification of potential miR-31 target-genes in Ewing Sarcoma
We identified miR-31 as strongest downregulated miRNA in the bone tumor Ewing sarcoma. To identify miR-31 targets in ES genome-wide gene expression profiles of TC71 cells transfected with miR-31 mimics or negative control (Life Technologies) generated in three independent experiments (a, b, c). Tota...
ORGANISM(S): Homo sapiens 
2012-10-23 | E-MTAB-1334 | biostudies-arrayexpress
GenomicsMethylation of Ewing sarcoma tumors (ICGC)
Ewing sarcoma (ES) is a primary bone tumor initiated by an EWSR1-ETS gene fusion. To characterize the methylation of Ewing sarcoma, reduced representation bisulfite sequencing was performed.
EGAS00001002161 | EGA
TranscriptomicsMicroRNA expression profiling of Ewing sarcoma spheres vs. adherent cells
We have recently demonstrated that human paediatric mesenchymal stem cells can be reprogrammed toward a Ewing’s sarcoma family tumor (ESFT) cancer stem cell (CSC) phenotype by mechanisms that implicate microRNAs (miRNAs). Here, we show that the miRNA profile of ESFT CSC is shared by embryonic stem c...
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-31145 | biostudies-arrayexpress
TranscriptomicsA TARBP2-dependent miRNA expression profile determines cancer stem cell properties and provides new candidate therapeutic reagents in Ewing's sarcoma
This SuperSeries is composed of the following subset Series: GSE30513: MicroRNA expression profiling of Ewing sarcoma cancer stem cells GSE31144: MicroRNA expression profiling of Ewing sarcoma cell lines upon TARBP2 depletion GSE31145: MicroRNA expression profiling of Ewing sarcoma spheres vs. adher...
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-31146 | biostudies-arrayexpress
GenomicsGenomic landscape of Ewing sarcoma (ICGC project)
The Ewing sarcoma project aims to sequence 100 complete genomes of cells of patients suffering from this disease. It is an initiative of great projection, since this is the second most common bone tumor in children and teenagers. The goal of the project is to establish the catalogue of somatic mutat...
EGAS00001000855 | EGA
TranscriptomicsVariability in functional p53 reactivation by Prima-1Met/APR-246 in Ewing sarcoma
Though p53 mutations are rare in Ewing sarcoma, there is a strong indication that p53-mutant tumors form a particularly bad prognosis group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumor cells containing mutant-p53 in this subset of ES patients....
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-49967 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of Ewing sarcoma cell lines upon TARBP2 depletion
We have recently demonstrated that human paediatric mesenchymal stem cells can be reprogrammed toward a Ewing’s sarcoma family tumor (ESFT) cancer stem cell (CSC) phenotype by mechanisms that implicate microRNAs (miRNAs). Here, we show that the miRNA profile of ESFT CSC is shared by embryonic stem c...
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-31144 | biostudies-arrayexpress
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