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GenomicsNeuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons
PRJNA543517 | ENA
ProteomicsAMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
AMPA-type glutamate receptors (AMPARs), key elements in excitatory neuro-transmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled constituents of their proteome. Here we identify AMPAR complexes that transiently form in the en...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-10-17 | PXD006413 | Pride
Excitatory synaptic transmission Proteomic analysis Intellectual disability Ampa-receptor biogenesis complexes 
GenomicsParaventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits
Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits
PRJNA1050595 | ENA
GenomicsParaventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits [RNA-seq]
Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits [RNA-seq]
PRJNA1059619 | ENA
TranscriptomicsNeuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons
The autism-associated synaptic-adhesion gene Neuroligin-4 (NLGN4) is poorly conserved evolutionarily, limiting conclusions from Nlgn4 mouse models for human cells. Here, we show that the cellular and subcellular expression of human and murine Neuroligin-4 differ, with human Neuroligin-4 primarily ex...
ORGANISM(S): Homo sapiens 
2019-06-27 | GSE131428 | GEO
TranscriptomicsRBFOX3/NeuN is required for hippocampal circuit balance and function
RBFOX3 mutations are linked to epilepsy and cognitive impairments, but the underlying pathophysiology of these disorders is poorly understood. Here we report replication of human symptoms in a mouse model with disrupted Rbfox3. Rbfox3 knockout mice displayed increased seizure susceptibility and decr...
ORGANISM(S): Mus musculus 
2016-07-26 | E-GEOD-84786 | biostudies-arrayexpress
ProteomicsAlternatively spliced mini exon B in PTPRD regulates hippocampal excitatory synapses through trans synaptic PTPRD IL1RAP interaction
PTP?, encoded by PTPRD, is implicated in various neurological, psychiatric, and neurodevelopmental disorders, but the underlying mechanisms remain unclear. PTP? trans-synaptically interacts with multiple postsynaptic adhesion molecules, which involves its extracellular alternatively spliced mini-exo...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-06-04 | MSV000094934 | MassIVE
UnknownSTK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
Not available
S-EPMC7366740 | biostudies-literature
UnknownNeddylation regulates excitatory synaptic transmission and plasticity.
Not available
S-EPMC6884593 | biostudies-literature
TranscriptomicsActivity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons
Excitatory synapses occur mainly on dendritic spines, and spine density is usually correlated with the strength of excitatory synaptic transmission. We report that Nr4a1, an activity-inducible gene encoding a nuclear receptor, regulates the density and distribution of dendritic spines in CA1 pyramid...
ORGANISM(S): Mus musculus 
2016-01-13 | E-GEOD-76805 | biostudies-arrayexpress
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