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TranscriptomicsLongitudinal expression data from CD8+ T cells responding to LCMV-Armstrong or LCMV-Clone 13
During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections...
ORGANISM(S): Mus musculus 
2012-11-23 | E-GEOD-41867 | biostudies-arrayexpress
GenomicsRNA-sequencing of ex vivo exhausted human antigen-specific T cells
Tumor-specific T cells are frequently exhausted by chronic antigenic stimulation. To explore new pathways for reinvigoration of anti-tumor immune functions, we developed a human ex vivo exhaustion model by repetitive antigenic stimulation of primary CD8 T cells. This results in T cells that resemble...
EGAS00001006794 | EGA
TranscriptomicsComparison of gene expression profiles of HIV-specific CD8 T cells from controllers and progressors
CD8+ T cells in chronic viral infections like HIV develop functional defects such as loss of IL-2 secretion and decreased proliferative potential that are collectively termed exhaustion1. Exhausted T cells express increased levels of multiple inhibitory receptors, such as Programmed Death 1 (PD-1)...
ORGANISM(S): Homo sapiens 
2010-10-03 | E-GEOD-24081 | biostudies-arrayexpress
TranscriptomicsMolecular signature of CD8+ T cell exhaustion in metastases but not in peripheral blood from melanoma patients
In chronic viral infections such as HIV-1, HBV and HCV, CD8+ T cells may become M-bM-^@M-^]exhaustedM-bM-^@M-^], characterized by progressive functional deficiency. Recently, the underlying mechanisms have been characterized by molecular profiling of virus-specific CD8+ T cells. In contrast, only li...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-24536 | biostudies-arrayexpress
GenomicsEffect of HPK1 inhibitor on exhausted CD8 T cells
Effect of HPK1 inhibitor on exhausted CD8 T cells
PRJNA906090 | ENA
TranscriptomicsscRNA-seq characterisation of in vitro-generated CD8+ exhausted human T cells
scRNA-seq was performed to characterise an in vitro model of T cell exhaustion. CD8+ T cells from two donors underwent chronic stimulation to induce exhaustion and samples were collected from multiple points across the protocol to examine the subsets and transcriptional signatures present.
ORGANISM(S): Homo sapiens 
2026-05-31 | E-MTAB-15435 | biostudies-arrayexpress
GenomicsEffect of bryostatin-1 on in vitro exhausted CD8+ T cells
Effect of bryostatin-1 on in vitro exhausted CD8+ T cells
PRJNA1198962 | ENA
TranscriptomicsTranscription profiling by array of CD8 T cells from healthy individuals that express high levals of Programmed Death-1 protein
T cell dysfunction is an important feature of many chronic viral infections. In particular, it was shown that PD-1 regulates T cell dysfunction during chronic LCMV infection in mice and PD-1 high cells exhibit an intense exhausted gene signature. These findings were extended to human chronic infecti...
ORGANISM(S): Homo sapiens 
2011-01-11 | E-GEOD-26495 | biostudies-arrayexpress
GenomicsTumor-specific memory-like progenitor exhausted CD8+ T cell subsets diverge into terminally exhausted cells and long-lived memory T cells
Tumor-specific memory-like progenitor exhausted CD8+ T cell subsets diverge into terminally exhausted cells and long-lived memory T cells
PRJNA1491478 | ENA
ProteomicsDetermining changes in the oxidized proteome of human CD8+ T cells with enhancing proteasome activity
Chronic T cell receptor (TCR) stimulation, combined with adverse conditions in the tumor microenvironment (TME) such as hypoxia and nutrient deprivation, frequently results in T cell exhaustion. Exhausted T cells (TEX) experience oxidative stress, which causes an accumulation of oxidized proteins wi...
ORGANISM(S): Homo sapiens (Human) 
2026-03-12 | PXD070152 | Pride
Exhausted t cells (tex) Oxidative stress Proteasome 
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