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GenomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [ChIP-Seq]
We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in the exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mit...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-34295 | biostudies-arrayexpress
TranscriptomicsExpression by CD133+ cells isolated from the adult human exocrine pancreas
Expression from CD133+ cells isolated from adult human exocrine tissue was compared to a CD133-depleted cell population Islet-depleted exocrine tissue from three independent adult human cadaveric pancreata were cultured for four days in Miami media 1A. Following trypsinization, cells were isolated u...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-64854 | biostudies-arrayexpress
TranscriptomicsRNA-seq of purified human pancreatic dedifferentiated acinar cells and duct cells
Pancreatic acinar cells can dedifferentiate upon tissue injury and acquire ductal characteristics. This acquisition of duct cell features is critical in tumor development. Nevertheless, duct cells themselves are less prone for development of PDAC (pancreatic ductal adenocarcinoma) than dedifferentia...
ORGANISM(S): Homo sapiens 
2021-06-17 | E-MTAB-9386 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse PERK mutant vs. wild type
Molecular characterization of PERK's role in the mouse exocrine pancreas. Postnatal days 16, 19 and 32 were examined. Postnatal day 16 represents a stage immediately prior to severe cytological changes in the exPKO mice. Postnatal day 19 represents the initial stage of severe phenotypes in the ex...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4422 | biostudies-arrayexpress
TranscriptomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [RNA-Seq]
Two separate pools of three Flox or two Lrh1t-/- pancreas RNA preparations was subjected to the Illumina RNA-seq protocol. Examination of mRNA levels in induced Lrh1 pancreas knockout and wild-type mice.
ORGANISM(S): Mus musculus 
2011-11-30 | E-GEOD-34030 | biostudies-arrayexpress
Proteomicshoneybee proteome
The honeybee (Apis mellifera L.) is a eusocial insect that uses various chemical signals such as royal jelly (RJ) produced by the worker exocrine glands, to maintain the ‘physiology’ of its colony. The roles of worker hypopharyngeal glands (HpG) and the changes they undergo according to the division...
ORGANISM(S): Cellular Organisms 
2018-01-24 | PXD005918 | JPOST Repository
TranscriptomicsEpigenomic plasticity enables human pancreatic alpha to beta cell reprogramming
Insulin-secreting β cells and glucagon-secreting α cells maintain physiological blood glucose levels, and their malfunction drives diabetes development. Using ChIP sequencing and RNA sequencing analysis, we determined the epigenetic and transcriptional landscape of human pancreatic α, β, and exocrin...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-50386 | biostudies-arrayexpress
ProteomicsDeoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development
Pancreatic diseases including diabetes and exocrine insufficiency would benefit from therapies that reverse cellular loss and/or restore cellular mass. The identification of molecular pathways that influence cellular growth is therefore critical for future therapeutic generation. Deoxyhypusine synth...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-10-30 | MSV000099697 | MassIVE
TranscriptomicsTranscription profiling of cultured normal human islet tissue, islets treated with interferon alpha 2 beta, islet-depleted exocrine pancreas, pancreas, liver and kidney tissue
The purpose of this study was to identify mRNA transcripts encoding tissue restricted cell surface proteins on human islet tissue that, in turn, might serve as markers for determination of healthy, transplanted and/or diseased islet cell mass. Using oligonucleotide microarrays and clinical grade hu...
ORGANISM(S): Homo sapiens 
2007-04-06 | E-CBIL-27 | biostudies-arrayexpress
TranscriptomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function
This SuperSeries is composed of the following subset Series: GSE34030: LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [RNA-Seq] GSE34295: LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-34296 | biostudies-arrayexpress
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