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ProteomicsBiochemical and Structural Basif for Differential Inhibitor Sensitivity of EGFR with Distinct Exon 19 Mutaions
Tyrosine kinase inhibitors (TKIs) are used to treat non-small cell lung cancers (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain (TKD). We studied structural basis of differential TKI sensitivity among EGFR exon 19 mutants by HDX-MS.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037374 | Pride
Exon 19 Hdx-ms Egfr 
ProteomicsThe structural dynamics of EGFR exon 19 mutants
Tyrosine kinase inhibitors (TKIs) are used to treat non-small cell lung cancers (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain (TKD). TKI responses vary across tumors driven by the heterogeneous group of exon 19 deletions and mutations, but the mole...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037355 | Pride
Exon 19 Hdx-ms Egfr 
ProteomicsThe strutural dynamics of EGFR Exon 19 mutants
Tyrosine kinase inhibtors are used to treat non-small cell lung cancers (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain (TKD). We characterized the dynamics of purified EGFR exon 19 kinase domain mutants by HDX-MS with or withour erlotinib, one of th...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037448 | Pride
Hdx-ms Egfr Exon19 
TranscriptomicsExon-level expression profiling of normal colonic mucosa samples.
These samples have been analyzed for global alternative splicing variation on exon-level expression data using the FIRMA algorithm. We have identified and described transcriptome instability as a genome-wide, pre-mRNA splicing related characteristic of solid cancers. This Series consists of 19 norma...
ORGANISM(S): Homo sapiens 
2014-08-13 | E-GEOD-42690 | biostudies-arrayexpress
TranscriptomicsIntragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition [RNA-Seq]
Although the function of DNA methylation in gene promoter regions is well established in transcriptional repression, the function of the evolutionarily conserved widespread distribution of DNA methylation in gene body regions remains incompletely understood. Here, we show that DNA methylation is enr...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-47488 | biostudies-arrayexpress
TranscriptomicsExon and junction microarrays detect widespread mouse strain- and sex-bias expression differences
71 liver RNA samples from three mouse strains - DBA/2J, C57BL/6J and C3H/HeJ - were profiled using a custom-designed microarray monitoring exon and exon-junction expression of 1,020 genes representing 9,406 exons. Gene expression was calculated via two different methods, using the 3'-most exon prob...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-10736 | biostudies-arrayexpress
GenomicsIntragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition [ChIP-Seq]
Although the function of DNA methylation in gene promoter regions is well established in transcriptional repression, the function of the evolutionarily conserved widespread distribution of DNA methylation in gene body regions remains incompletely understood. Here, we show that DNA methylation is enr...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-47677 | biostudies-arrayexpress
TranscriptomicsGlobal Promotion of Alternative Internal Exon Usage by mRNA 3' End Formation Factors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-60392 | biostudies-arrayexpress
UnknownThe exon 13 duplication in the BRCA1 gene is a founder mutation present in geographically diverse populations. The BRCA1 Exon 13 Duplication Screening Group.
Not available
S-EPMC1287079 | biostudies-literature
TranscriptomicsFrom mouse to humans: detecting preventing vaccination targets associated to breast cancer stem cells. Exon-level analysis
TuBo cell line (E) was compared to passage 1 (P1), 2 (P2) and 3 (P3) mammospheres to detect specific transcription isoforms associated to cancer stem cell. TuBo cell line (E) was compared to passage 1 (P1), 2 (P2) and 3 (P3) mammospheres. Exon-level transcription profiling was done using Affimetrix ...
ORGANISM(S): Mus musculus 
2013-11-30 | E-GEOD-21475 | biostudies-arrayexpress
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