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MetabolomicsMetabolomic Profiling of the Striatum in Shank3 Knockout ASD Rats: Effects of Early Swimming Regulation

OBJECTIVE: This study aimed to investigate the regulatory impact of early swimming intervention on striatal metabolism in Shank3 gene knockout ASD model rats.

METHODS: Shank3 gene knockout exon 11-21 male 8-day-old SD rats were used as experimental subject...

2024-09-27 | MTBLS8577 | MetaboLights
ProteomicsMinimal expression of dysferlin prevents development of muscular dystrophy in dysferlin exon 40a knockout mice
Dysferlin is an essential muscle membrane repair protein and autosomal recessive mutations in its gene result in progressive muscular dystrophies collectively called dysferlinopathies. We previously showed that calpain-mediated cleavage within dysferlin exon 40a releases a 72kDa C-terminal minidysfe...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035393 | Pride
Muscular dystrophy Exon knockout Mice Dysferlin 
ProteomicsMinimal expression of dysferlin prevents development of muscular dystrophy in dysferlin exon 40a knockout mice (second dataset)
Dysferlin is an essential muscle membrane repair protein and autosomal recessive mutations in its gene result in progressive muscular dystrophies collectively called dysferlinopathies. We previously showed that calpain-mediated cleavage within dysferlin exon 40a releases a 72kDa C-terminal minidysfe...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035918 | Pride
Muscular dystrophy Exon knockout Mice Dysferlin 
ProteomicsPhenotypic characterization of a Col6a3 knockout mouse model targeting exon 3
Mutations in COL6A3 lead to collagen VI-related myopathies due to COL6A3 loss. Therefore, studying the consequence of Col6a3 deregulated expression in mouse models is relevant, but the Col6a3 knockout mouse models currently available through a public repository does not entirely abolish COL6A3 prote...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD057310 | Pride
Mass spectrometry Muscular dystrophy Col6a3 Exon 3 Phenotype 
TranscriptomicsDifferential gene expression caused by Dicer knockout in small intestine
Dicer knockout cause lipid metabolism dysregulation in small intestine. Analyses of transcriptomics and proteomics reveal key enzymes affected by Dicer knockout. Conditional knockout of Dicer in adult mice
ORGANISM(S): Mus musculus 
2012-01-07 | E-GEOD-34905 | biostudies-arrayexpress
TranscriptomicsDifferential expression caused by Dicer knockout in small intestine
This SuperSeries is composed of the following subset Series: GSE34905: Differential gene expression caused by Dicer knockout in small intestine GSE34909: Differential miRNA expression caused by Dicer knockout in small intestine Refer to individual Series
ORGANISM(S): Mus musculus 
2012-01-07 | E-GEOD-34910 | biostudies-arrayexpress
GenomicsComparative Transcriptomic Analysis of Embryonic Hearts in Atf4 Exon 2 and Exon 2–3 Conditional Knockout Mice
Comparative Transcriptomic Analysis of Embryonic Hearts in Atf4 Exon 2 and Exon 2–3 Conditional Knockout Mice
PRJNA1298246 | ENA
TranscriptomicsDifferential Response Following Spinal Cord Injury in EphA4 Knockout
Mice lacking the developmental axon guidance molecule EphA4 have previously been shown to exhibit extensive axonal regeneration and functional recovery following spinal cord injury. To assess mechanisms by which EphA4 may modify the response to neural injury, a microarray was performed on spinal co...
ORGANISM(S): Mus musculus 
2012-05-23 | E-GEOD-34430 | biostudies-arrayexpress
TranscriptomicsDifferential miRNA expression caused by Dicer knockout in small intestine
Dicer knockout cause lipid metabolism dysregulation in small intestine. Analyses of transcriptomics and proteomics reveal key enzymes affected by Dicer knockout. Conditional knockout of Dicer in adult mice
ORGANISM(S): Mus musculus 
2012-01-07 | E-GEOD-34909 | biostudies-arrayexpress
TranscriptomicsTestosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice
Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin (KISS1) do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated by these proteins in the hypothalamus have yet to be explored by genome-wide methods. Using micro-disse...
ORGANISM(S): Mus musculus 
2011-08-21 | E-GEOD-28383 | biostudies-arrayexpress
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