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ProteomicsProteins binding in vitro to normal and mutant FMR1 5'UTR mRNA
Expanded CGG repeats in the 5’UTR of fragile X messenger ribonucleoprotein 1 (FMR1) gene are translated to mutant protein containing polyglycine stretches (FMRpolyG), which evoke development of neurodegenerative disorder the fragile X-associated tremor/ataxia syndrome (FXTAS). However, little is kno...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD053905 | Pride
Fmr1 Igf2bp3 Expanded cgg repeats Rna pull down Ran translation 
UnknownIGF2BPs directly regulate the noncanonical translation of toxic proteins from mutant FMR1 mRNA containing expanded CGG repeats.
Not available
S-EPMC12808120 | biostudies-literature
UnknownTranslation of Expanded CGG Repeats into FMRpolyG Is Pathogenic and May Contribute to Fragile X Tremor Ataxia Syndrome.
Not available
S-EPMC5263258 | biostudies-literature
UnknownShort antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats.
Not available
S-EPMC7904788 | biostudies-literature
UnknownTyrosine Peptides Alleviates Multifaceted Toxicity Linked to Expanded CGG Repeats in Fragile X‑Associated Tremor/Ataxia Syndrome.
Not available
S-EPMC12171881 | biostudies-literature
UnknownReplisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility.
Not available
S-EPMC2837601 | biostudies-literature
UnknownAbundancy of polymorphic CGG repeats in the human genome suggest a broad involvement in neurological disease.
Not available
S-EPMC7844047 | biostudies-literature
UnknownA native function for RAN translation and CGG repeats in regulating fragile X protein synthesis.
Not available
S-EPMC7668390 | biostudies-literature
UnknownQuantitative Evaluation of Toxic Polyglycine Biosynthesis and Aggregation in Cell Models Expressing Expanded CGG Repeats.
Not available
S-EPMC6018535 | biostudies-literature
UnknownCrystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndrome.
Not available
S-EPMC3167596 | biostudies-literature
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