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ProteomicsMalaria Hepatocyte HC-04.J7 Project
Characterization of three hepatocyte cell lines (2 parental and 1 clone), under two different media conditions. Parental cell lines HepG2 and HC-04, single cell cloned from HC-04 defined as HC-04.J7. The goal of the project initially was to investigate the invasion of hepatocytes by Plasmodium falci...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD008613 | Pride
Malaria Human liver Hepatocyte Plasmodium falciparum Lc-ms/ms 
TranscriptomicsIdentification of genes modulated by JIB-04 in lung cancer cells
JIB-04 is an inhibitor of Jumonji histone demethylases identified through a cell based screen that measures the reactivation of an epigenetically silenced transgene. The active JIB-04 E-isomer shows selectivity for cancer vs. normal cells affecting both transcriptional patterns and cell viability in...
ORGANISM(S): Homo sapiens 
2013-07-08 | E-GEOD-46632 | biostudies-arrayexpress
MetabolomicsMaHPIC Experiment 23: Metabolomics from Macaca mulatta infected with Plasmodium cynomolgi B strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute primary infection and relapses
MaHPIC Experimental Description: Malaria-naive male rhesus macaques (Macaca mulatta), approximately four years of age, were inoculated intravenously with salivary gland sporozoites produced and isolated at the Centers for Disease Control and Prevention from multiple Anopheles species (An. ...
2017-12-11 | MTBLS542 | MetaboLights
MetabolomicsMaHPIC Experiment 04: Metabolomics from Macaca mulatta infected with Plasmodium cynomolgi B strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute primary infection and relapses
Malaria-naive male rhesus macaques (Macaca mulatta), approximately three years of age, were inoculated intravenously with salivary gland sporozoites produced and isolated at the Centers for Disease Control and Prevention from multiple Anopheles species (An. dirus, An. gambiae, a...
2017-12-01 | MTBLS517 | MetaboLights
MetabolomicsLiquid Chromatography-High-Resolution Mass Spectrometry-Based In Vitro Toxicometabolomics of the Synthetic Cathinones 4-MPD and 4-MEAP in Pooled Human Liver Microsomes
Synthetic cathinones belong to the most often seized new psychoactive substances on an international level. This study investigated the toxicometabolomics, particularly the in vitro metabolism of 2-(methylamino)-1-(4-methylphenyl)-1-pentanone (4-MPD) and 2-(ethylamino)-1-(4-methylphenyl)-1-pentanone...
2023-11-28 | MTBLS2218 | MetaboLights
ProteomicsTranscriptomic and Proteomic Response of HC-04 to hepatocyte growth factor (HGF)
The routine study of human malaria liver-stage biology in vitro is hampered by low infection efficiency of human hepatocellular carcinoma (HCC) lines (<0.1%), poor understanding of steady-state HCC biology, and lack of appropriate tools for trace sample analysis. HC-04 is the only HCC that supports ...
ORGANISM(S): Homo sapiens (Human) 
2014-02-17 | PXD000682 | Pride
Host-pathogen interaction Mass spectrometry Emt Human hepatocellular carcinoma Transcriptomics Malaria Proteomics 
Metabolomics4-octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous metabolite itaconate has recently been reported to regulate macrophage function, but its precise mechani...
2019-10-02 | MTBLS1140 | MetaboLights
ProteomicsExperiment 04: Macaca mulatta infected with Plasmodium cynomolgi B strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute primary infection and relapses.
Malaria-naive male rhesus macaques (Macaca mulatta), approximately three years of age, were inoculated intravenously with salivary gland sporozoites produced and isolated at the Centers for Disease Control and Prevention from multiple Anopheles species (An. dirus, An. gambiae, and An. stephensi) and...
ORGANISM(S): Plasmodium cynomolgi strain B Macaca mulatta (Rhesus macaque) 
2019-03-13 | PXD007774 | Pride
Uga Artemether Shotgun Mahpic Malaria Plasmodium cynomolgi Emory Experiment 04 Systems biology Macaca mulatta 
MetabolomicsCompanilactobacillus alimentarius Y4 alleviates salmonella-induced intestinal inflammation by regulating gut microbiota and its metabolites
The emergence of ciprofloxacin-resistant Salmonella poses a significant challenge to the development of new drugs. Probiotics that inhibit ciprofloxacin-resistant Salmonella offer a safer alternative with fewer side effects than chemical antibiotics and drugs. Here, a strain of Companilactobacillus ...
2025-07-26 | MTBLS12777 | MetaboLights
MetabolomicsInhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control - NMR data

The global type 2 diabetes epidemic is a major health crisis and there is a critical need for innovative strategies to fight it. Although the microbiome plays important roles in the onset of insulin resistance (IR) and low-grade inflammation, the microbial compounds regulating these phenomena rem...

2025-10-20 | MTBLS12989 | MetaboLights
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