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MetabolomicsUntargeted metabolomics analysis of gingival tissue in patients with severe periodontitis
Periodontitis, as a chronic inflammatory condition, its initiating factor is the plaque biofilm. The inflammation starts in the gingival tissue, if left untreated, may progress to severe periodontitis and cause bone and tooth loss. The purpose of this study was to determine the potential metabolic b...
2026-09-08 | MTBLS8357 | MetaboLights
MetabolomicsGut commensal Odoribacter splanchnicus alleviates hyperlipidemic periodontitis via the β-GPA-TLR4 axis

Background: Hyperlipidemia is a well-established systemic metabolic disorder and a significant risk factor for periodontitis, a localized inflammatory condition; however, the precise mechanisms underpinning this comorbidity remain uncharacterized. Emerging evidence implicates the gut microbiota a...

2026-06-08 | MTBLS13125 | MetaboLights
MetabolomicsOral dysbiosis initiates periodontal disease in experimental kidney disease

BACKGROUND AND HYPOTHESIS: It is presently unclear why there is a high prevalence of periodontal disease in individuals living with chronic kidney disease. Whilst some have argued that periodontal disease causes chronic kidney disease, we hypothesized that alterations in saliva ...

2025-09-04 | MTBLS1833 | MetaboLights
GenomicsTriggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis
PRJNA1246123 | ENA
TranscriptomicsTranscriptomes in Healthy and Diseased Gingival Tissues
We examined gene expression signatures in healthy and diseased gingival tissues in 90 patients. Analysis of the gingival tissue transcriptome in states of periodontal health and disease may reveal novel insights of the pathobiology of periodontitis. Keywords: gingival tissue disease state analysis N...
ORGANISM(S): Homo sapiens 
2008-12-22 | E-GEOD-10334 | biostudies-arrayexpress
ProteomicsProbing the Salivary Proteome for Prognostic Biomarkers in Response to Non-Surgical Management of Periodontitis
This prospective study aimed to investigate salivary proteome changes in periodontitis patients in response to treatment. Ten systemically healthy, non-smokers with stage III, grade C periodontitis (32-43yrs, F:M:5:5) underwent non-surgical periodontal treatment. Saliva (n=30) was collected pre- (T0...
ORGANISM(S): Homo sapiens (Human) 
2024-06-10 | PXD043901 | Pride
Label-free quantitative proteomics Periodontal treatment Biomarkers Saliva Periodontitis 
UnknownMinocycline reduces alveolar bone loss and bone damage in Wistar rats with experimental periodontitis.
Not available
S-EPMC11451981 | biostudies-literature
UnknownBiochanin A alleviates gingival inflammation and alveolar bone loss in rats with experimental periodontitis.
Not available
S-EPMC7654219 | biostudies-literature
GenomicsProtective efficacy and related mechanism of deinoxanthin in experimental animal and cell models of periodontitis
Protective efficacy and related mechanism of deinoxanthin in experimental animal and cell models of periodontitis
PRJNA1305312 | ENA
UnknownHMGB1 localization during experimental periodontitis.
Not available
S-EPMC3945472 | biostudies-literature
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