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MetabolomicsBacterial extracellular vesicles as recyclable nutrient reservoirs

Bacterial extracellular vesicles (EVs) are known to mediate intercellular communication, virulence, and immune modulation. Here we show that bacteria can utilise EVs also as recyclable nutrient reservoirs. Using Bacillus cereus as a model organism, we demonstrate that EVs exhibit distin...

2026-02-18 | MTBLS13260 | MetaboLights
MetabolomicsMultiple roles of extracellular vesicles in promoting microbial driven elemental cycle

Microbial driven manganese (Mn) reduction influences the geochemical cycling of Mn and the environmental fate of various organic and inorganic substances. Extracellular vesicles (EVs) are known to impact microbial metabolic activities, but their specific role in Mn reduction remains arcane. Here,...

2025-07-16 | MTBLS12724 | MetaboLights
MetabolomicsMulti-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling.

Microbiota-released extracellular vesicles (MEVs) have emerged as a key player in intercellular signaling. However, their involvement in the gut-brain axis has been poorly investigated. In this study, we aimed to investigate the cargo capacity of MEVs for bioactive metabolites and their interacti...

2025-08-12 | MTBLS8494 | MetaboLights
MetabolomicsThe lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in colorectal cancer (CRC) evolution has not been repo...
2024-10-01 | MTBLS10323 | MetaboLights
MetabolomicsFunctional specialization of bacterial cellular and extracellular fractions contributes to polysaccharide degradation

Bacteroides thetaiotaomicron (Bt), a key commensal of the human gut microbiota, exhibits robust capacity to degrade dietary polysaccharides via carbohydrate-active enzymes (CAZymes). However, the exact spatial distribution and the functional coordination of these enzymes remain poor...

2026-03-27 | MTBLS14156 | MetaboLights
MetabolomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Extracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1221 | MetaboLights
TranscriptomicsLongSAGE during the initiation of ligninolytic enzymes production in Phanerochaete chrysosporium
White rot fungi are able to degrade woody lignin and other persistent organic compounds including artificial chemicals (e.g. chlorinated dioxin) in secondary metabolism. This ability has potential in a wide range of biotechnological applications including remediation of organopollutants and the indu...
ORGANISM(S): Phanerochaete chrysosporium 
2007-12-30 | E-GEOD-6649 | biostudies-arrayexpress
ProteomicsProteomics of exovesicle-enriched fraction of Norway spruce
Exovesicle-enriched fraction was isolated from the culture medium of tissue-cultured cells of Norway spruce during extracellular lignin formation and when lignin formation was hindered by scavenging of H2O2 from the culture medium. Proteomic analysis was conducted to investigate the protein cargo of...
ORGANISM(S): Picea Abies (ncbitaxon:3329) 
2023-05-16 | MSV000091958 | MassIVE
ProteomicsExtracellular Matrix Analysis of Human Varicose Veins
To understand the consequences of venous hypertension, normal and varicose veins were evaluated using proteomics approaches targeting the extracellular matrix.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-17 | MSV000080062 | MassIVE
ProteomicsProteomics of exovesicle-enriched fraction of Norway Spruce, non-EDTA-extracted samples
Exovesicle-enriched fraction was isolated from the culture medium of tissue-cultured cells of Norway spruce during extracellular lignin formation and when lignin formation was hindered by scavenging of H2O2 from the culture medium. Proteomic analysis was conducted to investigate the protein cargo of...
ORGANISM(S): Picea Abies (ncbitaxon:3329) 
2023-06-30 | MSV000092312 | MassIVE
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