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ProteomicsExtracellular matrix proteome remodeling with substrate stiffness
Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092971 | MassIVE
ProteomicsProteomic and degradomic signatures of extracellular matrix remodeling in calcific aortic valve
Calcific aortic valve disease (CAVD) is the most common valvular heart disease in older adults, but no medical therapy is currently able to halt or reverse its progression, partly because the molecular mechanisms of valve remodeling remain incompletely understood. Here, we aimed to dissect the extra...
ORGANISM(S): Homo sapiens (Human) 
2026-05-29 | PXD073246 | Pride
Aortic valve stenosis Extracellular matrix remodeling proteomics Calcific aortic valve disease Collagen post-translational modifications 
ProteomicsProteomics analysis of extracellular matrix remodeling during zebrafish heart regeneration
Adult zebrafish, in contrast to mammals, are able to regenerate their hearts in response to injury or experimental amputation. Our understanding of the cellular and molecular bases that underlie this process, although fragmentary, has increased significantly over the last years. However, the role of...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2019-08-22 | PXD011627 | Pride
Proteomic analysis Heart regeneration Extracellular matrix 
ProteomicsTargeted proteomic and bioinformatic investigation of extracellular matrix remodeling in hAEC-EV-mediated corneal repair
Human amniotic epithelial cell-derived extracellular vesicles (hAEC-EVs) have shown therapeutic potential in corneal injury repair; however, the underlying molecular mechanisms, particularly those related to extracellular matrix (ECM) remodeling, remain incompletely understood.
ORGANISM(S): Oryctolagus Cuniculus 
2026-03-11 | PXD075526 |
ProteomicsSecretome of rat smooth muscle cells with stretch
The extracellular matrix (ECM) is fundamental to cellular and tissue structural integrity and provides mechanical cues to initiate diverse biological functions1. The quality and quantity of ECM determines tissue stiffness and controls gene expression, cell fate, and cell cycle progression in various...
ORGANISM(S): Rattus Rattus (black Rat) 
2020-03-18 | PXD013915 | JPOST Repository
ProteomicsProteomic analysis of extracellular matrix remodeling during zebrafish heart regeneration
Adult zebrafish, in contrast to mammals, are able to regenerate their hearts in response to injury or experimental amputation. Our understanding of the cellular and molecular bases that underlie this process, although fragmentary, has increased significantly over the last years. However, the role of...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2019-08-26 | PXD010092 | Pride
Extracellular matrix  heart regeneration 
ProteomicsExtracellular matrix remodeling enhancing astrocyte lysosome pathway to reverse memory defected in Alzheimer’s disease
Extracellular matrix (ECM) remodeling is strongly linked to Alzheimer’s disease (AD) risk, but its functions are not fully understood. Here, we found that medial prefrontal cortex (mPFC) injection with chondroitinase ABC (ChABC) to remodel ECM reverses short-term memory loss and reduces Aβ depositio...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD046784 | Pride
Extracellular matrix remodeling Alzheimer's disease Astrocyte 
ProteomicsExtracellular Matrix Proteomics of Human Heart Failure.
MS analysis of human cardiac samples from left ventricles of patients undergoing cardiac transplantation due to ischaemic heart failure. Analysis of extracellular matrix enriched extracts.
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD024135 | Pride
Ischaemic heart failure Cardiac tissue Lc-msms. Extracellular matrix 
ProteomicsProteomic and degradomic signatures of extracellular matrix remodeling in calcific aortic valve stenotic
Calcific aortic valve disease (CAVD) is the most common valvular heart disease in older adults, but no medical therapy is currently able to halt or reverse its progression, partly because the molecular mechanisms of valve remodeling remain incompletely understood. Here, we aimed to dissect the extra...
ORGANISM(S): Homo sapiens (Human) 
2026-05-29 | PXD070758 | Pride
Calcific aortic valve disease Collagen post-translational modifications Aortic valve stenosis Extracellular matrix remodeling proteomics 
ProteomicsProteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury: control, guanidine
The aim of the present study is to characterize ECM remodeling after myocardial infarction by applying a proteomics method based on ECM enrichment and MS analysis to a porcine model of ischemia/reperfusion injury. The human-like physiology and anatomy of pigs facilitate comparisons of different car...
ORGANISM(S): Sus scrofa (Pig) 
2016-04-07 | PXD003918 | Pride
Heart Pig Extracellular matrix 
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