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MetabolomicsBacterial extracellular vesicles as recyclable nutrient reservoirs

Bacterial extracellular vesicles (EVs) are known to mediate intercellular communication, virulence, and immune modulation. Here we show that bacteria can utilise EVs also as recyclable nutrient reservoirs. Using Bacillus cereus as a model organism, we demonstrate that EVs exhibit distin...

2026-02-18 | MTBLS13260 | MetaboLights
MetabolomicsLipidomic analysis of Toxoplasma gondii extracellular vesicles across host cell types

Introduction. Toxoplasma gondii is an obligate intracellular parasite with an exceptional capacity to colonize a broad range of host species and cell types. Successful infection depends on its ability to manipulate host metabolism, including lipid pathways that are essential for membrane biogenes...

2026-02-11 | MTBLS13253 | MetaboLights
MetabolomicsMultiple roles of extracellular vesicles in promoting microbial driven elemental cycle

Microbial driven manganese (Mn) reduction influences the geochemical cycling of Mn and the environmental fate of various organic and inorganic substances. Extracellular vesicles (EVs) are known to impact microbial metabolic activities, but their specific role in Mn reduction remains arcane. Here,...

2025-07-16 | MTBLS12724 | MetaboLights
MetabolomicsParallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia (Metabolomic analysis on extracellular vesicles)

Acute myeloid leukemia (AML) is an aggressive disease with a high relapse rate. In this study, we map the metabolic profile of CD34+(CD38low/-) AML cells and the extracellular vesicle signatures in circulation from AML patients at diagnosis. CD34+ AML cells display high antioxidant glutathione le...

2024-12-04 | MTBLS11746 | MetaboLights
MetabolomicsParallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia (Lipidomic analysis on extracellular vesicles)

Acute myeloid leukemia (AML) is an aggressive disease with a high relapse rate. In this study, we map the metabolic profile of CD34+(CD38low/-) AML cells and the extracellular vesicle signatures in circulation from AML patients at diagnosis. CD34+ AML cells display high antioxidant glutathione le...

2024-12-04 | MTBLS11523 | MetaboLights
MetabolomicsmiR-9394b from Lactobacillus paracasei extracellular vesicles targets iNOS to reprogram host NO-ornithine metabolism and ameliorate ulcerative colitis

Background Probiotics have attracted considerable interest for ulcerative colitis (UC); however, their efficacy is highly strain-specific and the underlying molecular mechanisms remain incompletely understood.

Results Accumulating evidence indicates that bacterial extracellular vesicles (BE...

2026-01-23 | MTBLS13753 | MetaboLights
MetabolomicsPrevention of acute graft-versus-host disease via single-dose administration of bioengineered extracellular vesicles
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for various hematological and immunologic diseases, but acute graft-versus-host disease (aGVHD) remains a major cause of morbidity and mortality. We previously discovered in patients and murine models that higher le...
2026-09-11 | MTBLS15633 | MetaboLights
TranscriptomicsCrosstalk between the effects of extracellular vesicles (Evs) and TNF on U937 human monocyte cell line
Under physiological conditions, extracellular vesicles (EVs) are present simultaneously in the extracellular compartment together with cytokines. Thus, we hypothesized that EVs in combination with cytokines induce different responses of monocyte cells compared to EVs or cytokines alone. Human monocy...
ORGANISM(S): Homo sapiens 
2013-06-19 | E-GEOD-47897 | biostudies-arrayexpress
TranscriptomicsOsteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells
Osteolineage cells represent one of the critical bone marrow niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs). Recent studies demonstrate that extracellular vesicles (EVs) regulate stem cell development via horizontal transfer of bioactive cargo, including...
ORGANISM(S): Homo sapiens 
2016-10-05 | E-MTAB-4560 | biostudies-arrayexpress
MetabolomicsA reductionist approach using primary and metastatic cell-derived extracellular vesicles reveals hub proteins associated with oral cancer prognosis
Not available
ORGANISM(S): Homo sapiens 
ST001755 | MetabolomicsWorkbench
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