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TranscriptomicsmRNA expression after siRNA-mediated knock down of Enhancer of zeste homolog 2 (Ezh2) in human umbilical vein endothelial cells
mRNA expression after Ezh2 knock down was analyzed to identify genes regulated by Ezh2. Human umbilical vein endothelial cells (HUVEC) were transfected with 25 nmol/L of control small interfering RNA (siRNA) (Silencer Select Negative Control Ambion, Austin, TX) or siRNA directed against Ezh2 (s4918;...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41610 | biostudies-arrayexpress
TranscriptomicsEpigenetic Maintenance of Stemness and Malignancy in Peripheral Neuroectodermal Tumors by EZH2
Chromatin modifications are increasingly recognized as a key mechanism in cancer. The histone methyl-transferase Enhancer of Zeste, Drosophila, Homolog 2 (EZH2) is the enzymatic subunit of the polycomb PRC2 complex and methylates histone H3K27, thereby, mediating gene silencing. Down-regulation of E...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-15890 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of EZH2 knockdown
Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 expression is significantly upregulated in MPNST. In our study, we investigated the function of EZH2 and the molecular mechanisms that are regulated by EZH2 in...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-46904 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiles of EZH2 activation
Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 expression is significantly upregulated in MPNST. In our study, we investigated the function of EZH2 and the molecular mechanisms that are regulated by EZH2 in...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-47476 | biostudies-arrayexpress
TranscriptomicsRNAi knock-down of EZH2 in mouse prostate cancer cell line PC3
Gene list with increasing of expression in 2-fold or more after EZH2 knockdown in PC3 cells
ORGANISM(S): Homo sapiens 
2008-04-24 | E-MEXP-1581 | biostudies-arrayexpress
TranscriptomicsEffects of Brca1 knock-down on Ezh2 targeting
The Polycomb repressive complex 2 (PRC2) is important for the maintenance of stem cell pluripotency and suppression of cell differentiation by promoting histone H3 lysine 27 trimethylation (H3K27me3) and silencing expression of genes regulating differentiation. Here we show decreased expression of B...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-37321 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of NIPP1 and EZH2 in human prostate cell line PC-3 to investigate whether they regulate a common set of genes
NIPP1 and EZH2 contribute to the silencing of a common set of genes. Since both NIPP1 and EZH2 turned out to be essential for the initiation and maintenance of global H3K27 trimethylation, a key step in the PcG-mediated transcriptional regulation of genes, we have subsequently examined by DNA-micro...
ORGANISM(S): Homo sapiens 
2007-08-21 | E-TABM-128 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse G1ME cells following retroviral infection and shRNA-mediated knock-down of Suz12 and Ezh2
Suz12 in hematopoiesis II. Retroviral Infection and shRNA-mediated knock-down of Suz12 and Ezh2 in mouse G1ME cells.
ORGANISM(S): Mus musculus 
2008-07-03 | E-TABM-396 | biostudies-arrayexpress
TranscriptomicsGene expression and microRNA profiles of EZH2 knockdown
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-47477 | biostudies-arrayexpress
TranscriptomicsmRNA expression after siRNA-mediated knock down of Enhancer of zeste homolog 2 (Ezh2) in human umbilical vein endothelial cells
mRNA expression after Ezh2 knock down was analyzed to identify genes regulated by Ezh2.
ORGANISM(S): Homo sapiens 
2012-10-16 | GSE41610 | GEO
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