Sort   by:  
 Page size 
TranscriptomicsEZH1 and EZH2 Co-Govern Histone H3-K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair
Polycomb protein group (PcG)-dependent trimethylation on H3-K27(H3K27me3) regulates identity of embryonic stem cells (SCs). How H3K27me3 governs adult SCs and tissue development is unclear. Here, we conditionally target H3-K27-methyltransferases Ezh2 and Ezh1 to address their roles in mouse skin hom...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-26616 | biostudies-arrayexpress
TranscriptomicsAnalysis of changes in gene expression in epidermal stem cells upon loss of Polycomb silencing
Although in vitro studies of embryonic stem cells have identified Polycomb repressor complexes (PRCs) as key regulators of differentiation, it remains unclear as to how PRC-mediated mechanisms control fates of multipotent progenitors in developing tissues. Here, we show that an essential PRC compone...
ORGANISM(S): Mus musculus 
2009-12-18 | E-GEOD-14045 | biostudies-arrayexpress
TranscriptomicsHistone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat
In Saccharomyces cerevisiae, ubiquitylation of histone H2B signals methylation of histone H3 at lysine residues 4 (K4) and 79. These modifications occur at active genes but are believed to stabilize silent chromatin by limiting movement of silencing proteins away from heterochromatin domains. In the...
ORGANISM(S): Saccharomyces cerevisiae 
2011-12-02 | E-GEOD-27934 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of Gli1-positive cells from different compartments of the adult mouse epidermis
Tomato-traced single cells from the interfollicular epidermis including the touch dome (Gli1-Tomato+/Sca1+) and the hair follicle (Gli1-Tomato+/Sca1-) were FACS-sorted, randomly sequenced and clustered into epidermal (sub-)populations.
ORGANISM(S): Mus musculus 
2023-12-08 | E-MTAB-6031 | biostudies-arrayexpress
Sort   by:  
 Page size