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MetabolomicsIdentification of metabolites of trifunctional sphingomyelin (TFSM1) in HeLa 229 cells infected with Chlamydia trachomatis

Chlamydia trachomatis is an obligate intracellular bacterial pathogen and a leading cause of sexually transmitted infections worldwide. During its biphasic developmental cycle, infectious, non-replicative elementary bodies alternate with replicative reticulate bodies within a membrane-bound intra...

2026-08-10 | MTBLS15303 | MetaboLights
TranscriptomicsH3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells [twins]
In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone posttranslational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown. Here, DNA methylati...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-52113 | biostudies-arrayexpress
TranscriptomicsH3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells [MSCs]
In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone posttranslational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown. Here, DNA methylati...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-52112 | biostudies-arrayexpress
TranscriptomicsHigh-resolution comparative genome hybridization survey of healthy individuals (chromosome 22)
HighRes-CGH arrays that utilize ≈385,000 distinct oligonucleotide probes to cover chromosome 22 at 85 bp resolution (tiling path step size) were designed and synthesized as previously described (Urban et al., Proc Natl Acad Sci U S A. 2006;103(12):4534-9; see also GSE4240 record). Here, two health...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-6010 | biostudies-arrayexpress
UnknownExtrachromosomal DNA-Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma.
Not available
S-EPMC12498097 | biostudies-literature
TranscriptomicsHuman variation in PolII and NF-KappaB binding (RNA-seq study uninduced by TNF-alpha)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19466 | biostudies-arrayexpress
TranscriptomicsHuman variation in PolII and NF-KappaB binding (RNA-seq study with TNF-alpha induced)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19481 | biostudies-arrayexpress
GenomicsHuman variation in PolII and NF-KappaB binding (ChIP-seq study with NF-KappaB)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19485 | biostudies-arrayexpress
GenomicsHuman variation in PolII and NF-KappaB binding (ChIP-seq study with Pol II)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Pan troglodytes 
2010-03-22 | E-GEOD-19484 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mice TRAF2/Casp-8LPC-KO tumors
This model was used to study the relationship between NF-kB and PCD regulation and generated mice with combined conditional ablation of Traf2 and Caspase-8 (TRAF2/Casp-8LPC-KO) in order to block apoptosis and specifically study the role of necroptosis in Traf2-deficient hepatocytes in vivo.
ORGANISM(S): Mus musculus 
2019-05-31 | E-MTAB-4598 | biostudies-arrayexpress
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