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ProteomicsCold-induced urticarial autoinflammatoy syndrome related to factor XII activation
Early onset urticarial rash with systemic inflammatory symptoms are hallmarks of hereditary autoinflammatory diseases caused by gene mutations of the innate immune pathway, e.g. nucleotide receptor protein 3 (NLRP3). However, in many cases genetic tests are negative, suggesting the existence of unre...
ORGANISM(S): Homo sapiens (Human) 
2010-01-10 | PXD016341 | Pride
Cleavage Activation Factor xii 
ModelsTerentyeva2015 - Mechanisms of XII activation
Mathematical model of the mechanism and kinetics of blood coagulation factor XII.
2018-08-16 | MODEL1808160001 | BioModels
UnknownFactor XII truncation accelerates activation in solution.
Not available
S-EPMC7379707 | biostudies-literature
ProteomicsAntithrombotic coating with sheltered positive charges prevents contact activation by controlling Factor XII-biointerface binding
The development of an antithrombotic surface that prevents coagulation activation without interfering with hemostasis is the “holy grail” for blood-contacting devices. Such an advance would restrain device-induced thrombogenesis, and decrease the need for anticoagulant use in conjunction with device...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054476 | Pride
Antithrombotic coating Surface-protein interaction Coagulation fxii 
UnknownMisfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation.
Not available
S-EPMC2518075 | biostudies-literature
UnknownCoagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis.
Not available
S-EPMC12402198 | biostudies-literature
UnknownA novel missense mutation in the factor XII gene in a litter of cats with factor XII deficiency.
Not available
S-EPMC5447966 | biostudies-literature
UnknownFactor XII mutations, estrogen-dependent inherited angioedema, and related conditions.
Not available
S-EPMC2920236 | biostudies-literature
UnknownModel for surface-dependent factor XII activation: the roles of factor XII heavy chain domains.
Not available
S-EPMC9131904 | biostudies-literature
UnknownFactor XII-driven coagulation traps bacterial infections.
Not available
S-EPMC12013512 | biostudies-literature
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