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TranscriptomicsContext-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk allele
IL-7 is a key factor in T-cell immunity and IL7R polymorphisms are implicated in autoimmune pathogenesis. IL7R mRNA is induced in stimulated monocytes in a genetically determined manner. Here we show monocyte surface and soluble IL7R (sIL7R) protein are markedly expressed in response to lipopolysacc...
ORGANISM(S): Homo sapiens 
2019-08-12 | E-MTAB-8207 | biostudies-arrayexpress
TranscriptomicsCustom MHC array analysis of lymphoblastoid cell lines
The human MHC is a paradigm for genomics, showing striking association with disease but functional variants remain largely unresolved. Using an original hybrid microarray (containing tiling and junction probes) for the MHC and accounting for known sequence diversity, we have drawn the first high-res...
ORGANISM(S): Homo sapiens 
2011-05-23 | E-GEOD-22453 | biostudies-arrayexpress
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