Fak John J - OmicsDI

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pride (2)

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Centre for Genomics and Computational Biology Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ Tel: +44 (0)20 7882 8266 | Fax: +44 (0)20 7882 3891 | Email: p.cutillas@qmul.ac.uk (1)
Reader in Centre for Genomics and Computational Biology Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ Tel: +44 (0)20 7882 8266 | Fax: +44 (0)20 7882 3891 | Email: p.cutillas@qmul.ac.uk www.bci.qmul.ac.uk/research/centre-profiles/haemato-oncology.html https://www.bci.qmul.ac.uk/en/staff/item/pedro-cutillas (1)

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FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

Cancer-associated fibroblasts (CAFs), although considered as the most abundant pancreatic ductal adenocarcinoma (PDAC) stromal cells playing a critical role in tumor progression and chemoresistance, are not yet directly druggable. Here we report that focal adhesion kinase (FAK) activity (evaluated b...

ORGANISM(S): Homo sapiens (Human)

2020-08-19 | PXD018899 | Pride

Low endothelial cell FAK expression reduces pancreatic ductal adenocarcinoma liver metastasis after gemcitabine treatment

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with a high level of liver metastasis. Despite substantial advances, resistance to therapy, including gemcitabine, is still a major obstacle to improved progression free survival. Recent studies have indicated that endothe...

ORGANISM(S): Mus musculus (Mouse)

2023-03-10 | PXD021542 | Pride

Endothelium Chemotherapy Focal adhesion kinase Tumour models Resistance Gemcitabine Phosphoproteomics Metastasis Pancreatic ductal adenocarcinoma Lc-ms/ms

Cancer associated fibroblast FAK regulates malignant cell metabolism.

Not available

S-EPMC7064590 | biostudies-literature

ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning.

Not available

S-EPMC9340553 | biostudies-literature

Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.

Not available

S-EPMC7272651 | biostudies-literature