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TranscriptomicsAge-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia
Despite the advances in our understanding of aging-associated behavioral decline, we know relatively little about how aging affect neural circuits that underlie specific behaviors. Specifically, we know little about how aging affect expression of genes in specific neural circuits. We have now addres...
ORGANISM(S): Aplysia californica 
2014-02-05 | E-GEOD-46618 | biostudies-arrayexpress
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [retrovirally infected ex vivo lymphoma]
Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-37791 | biostudies-arrayexpress
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state
This SuperSeries is composed of the following subset Series: GSE33474: Tristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [bone marrow B cells]. GSE37790: Tristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-37792 | biostudies-arrayexpress
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [bone marrow B cells].
Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-33474 | biostudies-arrayexpress
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [Lymphoma].
Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-37790 | biostudies-arrayexpress
TranscriptomicsSpatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation
Interaction of hematopoietic progenitors with the thymic stromal microenvironment induces them to proliferate, adopt the T cell fate, and asymmetrically diverge into multiple T lineages. Progenitors at various developmental stages are stratified among different regions of the thymus, implying that t...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-18281 | biostudies-arrayexpress
TranscriptomicsIdentification of E47 targets
In maturing T-lineage cells, the helix-loop-helix protein E47 has been shown to enforce a critical proliferation and developmental checkpoint commonly referred to as β selection. To examine how E47 regulates cellular expansion and developmental progression, we have used an E2A deficient lymphoma c...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-4784 | biostudies-arrayexpress
TranscriptomicsGene Expression profiling of Myc-induced lymphomagenesis
The ability of oncogenes to provoke cancer is harnessed by regulators that control cell proliferation or induce apoptosis, and bypass of these checkpoints is a hallmark of malignancies. Myc oncoproteins are overexpressed in ~70% of all cancers and induce numerous transcription targets that regulate ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-32239 | biostudies-arrayexpress
TranscriptomicsA global expression switch marks pachytene initiation during mouse male meiosis
Male spermatogenesis is an essential and complex developmental process with the purpose to gain totipotency and allow a whole new organism to develop upon fertilization. While single-gene based studies have provided insights into the mechanisms at work, global profiling is clearly required to deconv...
ORGANISM(S): Mus musculus 
2010-12-16 | E-GEOD-21447 | biostudies-arrayexpress
UnknownMetrics other than potency reveal systematic variation in responses to cancer drugs
Not available
2016-05-06 | LDS-1106 | LINCS
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