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ProteomicsMudPIT analysis of the Dbf4/Chiffon and Gcn5 complex in Drosophila
During evolution, there has been an expansion in the diversity of histone acetyltransferase Gcn5-containing complexes. All Gcn5 complexes share Sgf29 and Ada3 subunits, which together with their respective Ada2 homolog, enable nucleosomal HAT activity. In metazoans, including Drosophila, there are t...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2017-12-07 | MSV000081791 | MassIVE
TranscriptomicsThe effect of Dis3 knockdown on miRNA expression in Drosophila wing imaginal discs.
We investigated the effect on miRNA expression in Drosophila melanogaster wing imaginal discs following the knockdown of the 3'-5' exoribonuclease Dis3.
ORGANISM(S): Drosophila melanogaster 
2015-06-01 | E-MTAB-3569 | biostudies-arrayexpress
TranscriptomicsProbing the initiation and effector phases of the somatic piRNA pathway in Drosophila
Combining RNAi in cultured cells and analysis of mutant animals, we probed roles of known piRNA pathway components in the initiation and effector phases of transposon silencing. total RNA and RNA associated with Piwi was isolated and size-fractionated by PAGE into 19-29nt. These were processed and s...
ORGANISM(S): Drosophila melanogaster 
2010-10-25 | E-GEOD-24108 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of null Pacman/Xrn1 mutant Drosophila L3 wing imaginal discs
Two pcm null alleles (pcm14 and pcm15) were sequenced alongside respective wild-type controls (wild-type 1 and wild-type 2). Each genotype was replicated 3 times. Read depth was 12-17 million reads per replicate. Total RNA was prepared from Drosophila L3 larval wing imaginal discs.
ORGANISM(S): Drosophila melanogaster 
2016-07-03 | E-MTAB-3789 | biostudies-arrayexpress
TranscriptomicsThe let-7-Imp axis regulates aging of the Drosophila testis stem cell niche.
Adult stem cells support tissue homeostasis and repair throughout the life of an individual. However, numerous intrinsic and extrinsic changes occur with age that result in altered stem cell behavior and reduced tissue maintenance and regeneration. In the Drosophila testis, stem cells surround and c...
ORGANISM(S): Drosophila melanogaster 
2012-05-31 | E-GEOD-37041 | biostudies-arrayexpress
TranscriptomicsHierarchical rules for Argonaute loading in Drosophila
Drosophila Argonaute-1 and Argonaute-2 differ in function and small RNA content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by microRNAs. microRNA duplexes are intrinsically asymmetric, with one strand, the miR strand, preferentially entering AGO1 to recognize and regulate the...
ORGANISM(S): Drosophila melanogaster 
2009-11-15 | E-GEOD-17734 | biostudies-arrayexpress
TranscriptomicsCharacterisation of the in-vivo miRNA landscape in Drosophila ribonuclease mutants reveals Pacman mediated regulation of the highly conserved let-7 cluster during apoptotic processes
RNA extracted from Drosophila wandering L3 wing imaginal discs was 2S rRNA depleted and prepared for miRNA sequencing using the QIAseq miRNA Library kit. The experiment was performed on Pacman and Dis3L2 null mutants and their respective isogenic control lines with four replicates of each condition.
ORGANISM(S): Drosophila melanogaster 
2024-02-28 | E-MTAB-13781 | biostudies-arrayexpress
TranscriptomicsA genome-scale shRNA resource for transgenic RNAi in Drosophila
Existing transgenic RNAi resources in Drosophila utilize the expression of long double stranded hairpin RNAs and are powerful tools for the identification and characterization of genes involved in various processes. However, they are ineffective to knockdown genes during oogenesis, an important mode...
ORGANISM(S): Drosophila melanogaster 
2011-03-26 | E-GEOD-27039 | biostudies-arrayexpress
TranscriptomicsProcessing of Drosophila endo-siRNAs depends on a specific Loquacious isoform
Drosophila melanogaster expresses three classes of small RNAs, which are classified according to their mechanisms of biogenesis. MicroRNAs are ~22-23-nt, ubiquitously expressed small RNAs that are sequentially processed from hairpin-like precursors by Drosha/Pasha and Dcr-1/Loquacious complexes. Mic...
ORGANISM(S): Drosophila melanogaster 
2009-07-30 | E-GEOD-17171 | biostudies-arrayexpress
TranscriptomicsShutdown is a component of the Drosophila piRNA biogenesis machinery (smallRNA)
In animals, the piRNA pathway preserves the integrity of gametic genomes, guarding them against the activity of mobile genetic elements. This innate immune mechanism relies on distinct genomic loci, termed piRNA clusters, to provide a molecular definition of transposons, enabling their discriminatio...
ORGANISM(S): Drosophila melanogaster 
2012-06-30 | E-GEOD-38089 | biostudies-arrayexpress
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