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ProteomicsFam20C-LCMSMS - Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α
Family with sequence similarity 20C (Fam20C), the physiological Golgi casein kinase, phosphorylates numerous secreted proteins that are involved in a wide variety of biological processes. However, the role of Fam20C in regulating proteins in the endoplasmic reticulum (ER) lumen is largely unknown. H...
ORGANISM(S): Homo sapiens (Human) 
2018-05-30 | PXD009333 | Pride
Fam20c ero1 lcmsms 
TranscriptomicsGene mRNA levels in the bone of FAM20C KO mice VS WT mice (3-WK-old)
Family with sequence similarity 20-member C (FAM20C) is a new molecule that is highly expressed in the mineralized tissues of mammals. Genetic studies showed that the loss-of-function mutations in FAM20C were associated with human lethal osteosclerotic bone dysplasia (Raine Syndrome), indicating tha...
ORGANISM(S): Mus musculus 
2012-02-17 | E-MTAB-772 | biostudies-arrayexpress
ProteomicsFam20C interactome in the secretory pathway under ER stress
Accumulated unfolded proteins in the endoplasmic reticulum (ER) will trigger the unfolded protein response (UPR) to increase protein-folding capacity. The ER proteostasis and UPR signaling should be precisely and timely regulated. In the project, by unbiased proteomics analysis, we identify that the...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD016619 | Pride
Fam20c Pdi Er stress Phosphorylation 
GenomicsSecretory kinase FAM20C triggers adipocyte dysfunction inciting insulin resistance and inflammation in obesity
Secretory kinase FAM20C triggers adipocyte dysfunction inciting insulin resistance and inflammation in obesity
PRJNA1364024 | ENA
GenomicsFam20c regulates the calpain proteolysis system through phosphorylating Calpasatatin to maintain cell homeostasis
Fam20c regulates the calpain proteolysis system through phosphorylating Calpasatatin to maintain cell homeostasis
PRJNA976281 | ENA
TranscriptomicsEffect of Fam20C knockdown on gene expression in U251 glioma cells
To investigate the oncogenic role of Fam20C in glioma progression, we established U251 glioma cells in which Fam20C was knocked down by siRNA.
ORGANISM(S): Homo sapiens 
2026-09-29 | GSE348732 | GEO
TranscriptomicsSecretory kinase FAM20C triggers adipocyte dysfunction inciting insulin resistance and inflammation in obesity
Obesity is a major driver of type 2 diabetes (T2D) and related metabolic disorders, characterized by chronic inflammation and adipocyte dysfunction. However, the molecular triggers initiating these processes remain poorly understood. We identify FAM20C, a serine/threonine kinase, as an early obesity...
ORGANISM(S): Mus musculus 
2025-11-18 | GSE309948 | GEO
GenomicsFam20c regulates the calpain proteolysis system through phosphorylating Calpasatatin to maintain cell homeostasis
Background: The family with sequence similarity 20-member C (FAM20C) kinase, a Golgi casein kinase, which is responsible for phosphorylating the majority of the extracellular phosphoproteins within S-x-E/pS motifs, and is fundamentally associated with multiple biological processes to maintain cell p...
ORGANISM(S): Mus musculus 
2023-09-11 | GSE233445 | GEO
UnknownFAM20C directly binds to and phosphorylates Periostin.
Not available
S-EPMC7555550 | biostudies-literature
UnknownThe specific role of FAM20C in dentinogenesis.
Not available
S-EPMC4300304 | biostudies-literature
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