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MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
TranscriptomicsA diverse set of microRNAs and microRNA-like small RNAs in developing rice grains
Endogenous small RNAs, including microRNAs (miRNAs) and short-interfering RNAs (siRNAs), function as posttranscriptional or transcriptional regulators in plants. miRNA function is essential for normal development and therefore likely to be important in the growth of the rice grain. To investigate th...
ORGANISM(S): Oryza sativa 
2008-08-21 | E-GEOD-11014 | biostudies-arrayexpress
MetabolomicsGNPS - Puget Sound marine water
Paper title: Suspect and nontarget screening for contaminants of emerging concern in an urban estuary Author List: Tian Z, Peter KT, Gipe AD, Zhao HN, Hou F, Wark DA, Khangaonkar T, Kolodziej EP, James CA Citation: Environ Sci Technol. 2020, 54, 2, 889-901 Description: DDA analysis of nearshore mar...
ORGANISM(S): N/a 
2021-04-13 | MSV000087187 | GNPS
ProteomicsProteomics Informed by Transcriptomics for Characterising Active Transposable Elements and Genome Annotation in Aedes aegypti
The incomplete genome annotation of non-model organisms hampers molecular and proteomic studies. Proteomics informed by transcriptomics (PIT) is suited to non-model organisms because peptides are identified using transcriptomic, not genomic, data. Aedes aegypti is the mosquito vector for the (re-)em...
ORGANISM(S): Aedes aegypti aegypti 
2017-02-15 | PXD003799 | Pride
Lc-ms/ms Pit Aedes aegypti Proteomics informed by transcriptomics 
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
ProteomicsDifferentially and constantly expressed proteins identified through proteomic analysis of different Toxoplasma gondii field isolates carried out upon short- or long-term in vitro culture
Comparison of the proteomes of Toxoplasma gondii field isolates after short-term or long-term in vitro culture
ORGANISM(S): Toxoplasma gondii 
2025-10-06 | PXD067210 | Pride
Target deconvolution Model system Patho-biodiversity Eukaryote cell Equivalence tests Vaccine development 
TranscriptomicsTranscription profiling of rat and mouse granulosa cells infected with adenoviral vectors expressing two FOXO1 mutants reveals FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells
The forkhead box transcription factor FOXO1 is highly expressed in granulosa cells of growing follicles but is down-regulated by FSH in culture or by LH-induced luteinization in vivo. To analyze the function of FOXO1, we infected rat and mouse granulosa cells with adenoviral vectors expressing two F...
ORGANISM(S): Rattus norvegicus 
2009-04-25 | E-GEOD-15727 | biostudies-arrayexpress
UnknownA Strategy for Accessing Nanobody-Based Electrochemical Sensors for Analyte Detection in Complex Media.
Not available
S-EPMC9635334 | biostudies-literature
GenomicsRegulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Embryonic Stem Cells (ChIP-seq)
In this study, we mapped modification of lysine 4 and lysine 27 of histone H3 genome-wide in a series of mouse embryonic stem cells (mESCs) varying in DNA methylation levels based on knock-out and reconstitution of DNA methyltransferases (DNMTs). We extend previous studies showing cross-talk between...
ORGANISM(S): Mus musculus 
2016-08-02 | E-GEOD-77002 | biostudies-arrayexpress
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