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ProteomicsPTPRR interactome detection using PUP-IT (pupylation-based interaction tagging) Mass Spectrometry
To further stably express PTPRR (WT)-PafA or PTPRR (DA)-PafA in iPUP OVCAR5 cell, we subcloned PTPRR-WT or DA, respectively, into the PafA-IRES-EGFP plasmid. Each plasmid was packed into a lentivirus and then transduced into iPUP OVACR5 cells for 48 h. GFP-positive cells were sorted by flow cytometr...
ORGANISM(S): Homo sapiens (Human) 
2019-10-30 | PXD015352 | Pride
Lc-ms Ptprr 
ProteomicsAddressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via PROTAC-Mediated Degradation
The rate-limiting enzyme of salvage pathway for NAD+ synthesis, NAMPT, is aberrantly overexpressed in a variety of tumor cells and is a poor prognosis factor for patient survival. NAMPT plays a major role in tumor cell proliferation, acting concurrently as a NAD+ synthase and unexpectedly, an extrac...
ORGANISM(S): Homo Sapiens 
PXD028453 |
ProteomicsAddressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via two PROTAC-Mediated Degradation
The rate-limiting enzyme of salvage pathway for NAD+ synthesis, NAMPT, is aberrantly overexpressed in a variety of tumor cells and is a poor prognosis factor for patient survival. NAMPT plays a major role in tumor cell proliferation, acting concurrently as an NAD+ synthase and unexpectedly, an extra...
ORGANISM(S): Homo Sapiens 
2022-01-24 | PXD031185 |
ProteomicsFER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer
Tyrosine phosphorylation, orchestrated by tyrosine kinases and phosphatases, modulates a multi-layered signaling network in a time and space dependent manner. Dysregulation of this post-translational modification is inevitably associated with pathological diseases. Our previous work has demonstrated...
ORGANISM(S): Homo Sapiens 
2020-10-19 | PXD022084 |
UnknownA noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2.
Not available
S-EPMC7223722 | biostudies-literature
ProteomicsTHEMIS is a novel substrate and allosteric activator of SHP1, playing dual roles during T cell development
By combining strategies of substrate trapping for PTPs and pupylation-based interaction tagging (PUP-IT) for protein-protein interaction, we develop a systematic proximity labeling methodology PEPSI in identifying novel substrate for PTPs. We apply this approach to SHP1 and surprisingly, identified ...
ORGANISM(S): Homo Sapiens 
PXD028689 |
TranscriptomicsFL5.12 Bfl-1DC/p53DD-derived splenic tumors compared to the parental FL5.12 Bfl-1DC/p53DD cell line
The antiapoptotic Bcl-2 family member Bfl-1 is upregulated in many human tumors in which NF-kB is implicated, and contributes significantly to tumor cell survival and chemoresistance. We previously found that NF-kB induces transcription of bfl-1, and that the Bfl-1 protein is also regulated by the u...
ORGANISM(S): Mus musculus 
2010-03-23 | E-GEOD-18204 | biostudies-arrayexpress
UnknownCANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma.
Not available
S-EPMC5417793 | biostudies-literature
UnknownADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers.
Not available
S-EPMC10721152 | biostudies-literature
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