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UnknownGenomic analysis reveals that immune function genes are strongly linked to clinical outcome in the North Central Cancer Treatment Group n9831 Adjuvant Trastuzumab Trial.
Not available
S-EPMC4334774 | biostudies-literature
TranscriptomicsThe transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment.
Here we tracked transcriptome changes over ten human hematopoietic stem and early progenitor populations, defining the transcriptional dynamics underlying the first steps of commitment. Most of the transcriptional programs observed extended beyond lineage boundaries. In particular, multi-lymphoid pr...
ORGANISM(S): Homo sapiens 
2013-05-26 | E-GEOD-42414 | biostudies-arrayexpress
TranscriptomicsCharacterization of the single-cell (ES and MEF) transcriptional landscape by highly multiplex RNA-Seq
Our understanding of the development and maintenance of tissues has been greatly aided by large-scale gene expression analysis. However, tissues are invariably complex, and expression analysis of a tissue confounds the true expression patterns of its constitutent cell types. Here we describe a novel...
ORGANISM(S): Mus musculus 
2011-05-24 | E-GEOD-29087 | biostudies-arrayexpress
TranscriptomicsGenome-wide Expression Assay Comparison Across Frozen and Fixed Postmortem Brain Tissue Samples
Comparison between in vitro transcription- and cDNA-mediated annealing, selection and ligation (DASL)-based assays on brain-specific reference RNA, and postmortem frozen and formalin fixed brain tissue from autistic and control cases. Investigation of data preprocessing techniques for DASL-assayed ...
ORGANISM(S): Homo sapiens 
2012-04-02 | E-GEOD-28475 | biostudies-arrayexpress
TranscriptomicsA methyl-deviator epigenotype of estrogen-receptor-positive breast carcinoma is associated with malignant biology
We broadly profiled DNA methylation in breast cancers (n=351) and benign parenchyma (n=47) for correspondence with disease phenotype using formalin-fixed paraffin-embedded (FFPE) diagnostic surgical pathology specimens. Exploratory analysis revealed a distinctive primary invasive carcinoma subclass ...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-29428 | biostudies-arrayexpress
TranscriptomicsApplication of a low cost array-based technique - TAB-Array - for quantifying and mapping both 5mC and 5hmC at single base resolution.
5-hydroxymethylcytosine (5hmC), an oxidized derivative of 5-methylcytosine (5mC), has been implicated as an important epigenetic regulator of mammalian development. Current procedures use cost-prohibitive DNA sequencing methods to discriminate 5hmC from 5mC, limiting their accessibility to the scie...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-60225 | biostudies-arrayexpress
TranscriptomicsEvaluation of a New High-Dimensional miRNA Profiling Platform
We evaluated a new miRNA profiling platform that utilizes Illumina’s existing robust DASL chemistry as the basis for the assay. Using total RNA from five colon cancer patients and four cell lines, we evaluated the reproducibility of miRNA expression levels across replicates and with varying amoun...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-17346 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of Formalin-Fixed Parafin-Embedded Primary Breast Tumors DASL Cancer Panel
HER2-positive and HER2-negative samples are compared within this DASL Cancer Panel Platform Two-class comparison
ORGANISM(S): Homo sapiens 
2010-12-20 | E-GEOD-25231 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of Formalin-Fixed Parafin-Embedded Primary Breast Tumors Whole Genome DASL
HER2-positive and HER2-negative samples are compared within this Whole Genome Platform Two-class comparison
ORGANISM(S): Homo sapiens 
2010-12-20 | E-GEOD-25233 | biostudies-arrayexpress
UnknownNew insights into the genetic etiology of Alzheimer's disease and related dementias.
Not available
S-EPMC9005347 | biostudies-literature
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