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TranscriptomicsSpecies-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts
Most eukaryotic genes express mRNAs with alternative polyadenylation sites at their 3’ ends. Here we show that polyadenylated 3’ termini in three yeast species (S. cerevisiae, K. lactis, D. hansenii) are remarkably heterogeneous. Instead of a few discrete 3’ ends, the average yeast gene has an “en...
ORGANISM(S): Saccharomyces cerevisiae 
2013-07-03 | E-GEOD-47661 | biostudies-arrayexpress
TranscriptomicsIdentification of Novel Molecular Markers through Transcriptomic Analysis in Human Fetal and Adult Corneal Endothelial Cells
Corneal endothelium is composed of a monolayer of corneal endothelial cells (CECs) in the inner layer of cornea, which is essential for maintaining corneal transparency. In order to better characterize CECs in different developmental stages, we profiled mRNA transcriptomes in human fetal and adult c...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-GEOD-41616 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNA signatures during the differentiation of hESCs into retinal pigment epithelial cells
Retinal pigment epithelium (RPE) cells can be obtained through in vitro differentiation of both embryonic stem cell (ESC) and induced pluripotent stem cells (iPSC) for cell replacement therapy. We have previously identified 87 signature genes relevant to RPE cell differentiation and function through...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-37686 | biostudies-arrayexpress
UnknownGlobal analysis of mRNA isoform half-lives reveals stabilizing and destabilizing elements in yeast.
Not available
S-EPMC3939777 | biostudies-literature
TranscriptomicsSelective demethylation and altered gene expression are associated with ICF Syndrome in human induced pluripotent stem cells and mesenchymal stem cells
Immunodeficiency, Centromeric Instability, and Facial Anomalies Type I (ICF1) Syndrome is a rare genetic disease caused by mutations in DNMT3B, a de novo DNA methyltransferase. However, the molecular basis of how DNMT3B-deficiency leads to ICF1 pathogenesis is unclear. Induced pluripotent stem cell ...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-46030 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of mRNA isoform half-lives: identification of stabilizing and destabilizing elements in yeast
We measured half-lives of 21,248 mRNA 3’ isoforms in yeast by rapidly depleting RNA polymerase II from the nucleus and performing direct RNA sequencing throughout the decay process. Interestingly, the half-lives of mRNA isoforms from the same gene, including nearly identical isoforms, often vary wid...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-02 | E-GEOD-52286 | biostudies-arrayexpress
GenomicsIntegrated analysis of DNA methylation and RNA transcriptome during the differentiation of human pluripotent stem cells into retinal pigment epithelial cells
Using the paradigm of in vitro differentiation of hESCs/iPSCs into retinal pigment epithelial (RPE) cells, we have recently profiled mRNA and miRNA transcriptomes to define a set of RPE mRNA and miRNA signature genes implicated in directed RPE differentiation. In this study, in order to understand t...
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-43473 | biostudies-arrayexpress
TranscriptomicsAn epithelial-mesenchymal transition (EMT) gene signature predicts resistance to erlotinib and PI3K pathway inhibitors and identifies Axl as a novel EMT marker in non-small cell lung cancer.
Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, it...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-33072 | biostudies-arrayexpress
ProteomicsbeadsEnrichment_L1-L4
L1-L4 mixture, Beads enrichment, Heparin-IEX
ORGANISM(S): Caenorhabditis Elegans (c. Elegans) 
2016-12-31 | PAe005573 | PeptideAtlas
ProteomicswholeCellExtract_L4-stage
L4 stage, whole protein extact, Heparin-IEX
ORGANISM(S): Caenorhabditis Elegans (c. Elegans) 
2016-12-31 | PAe005556 | PeptideAtlas
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