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MetabolomicsMetabolomic analysis of alfalfa (Medicago sativa L.) root-symbiotic rhizobia responses under alkali stress
Alkaline salts (e.g., NaHCO3 and Na2CO3) causes more severe morphological and physiological damage to plants than neutral salts (e.g., NaCl and Na2SO4) due to differences in pH. The mechanism by which plants respond to alkali stress is not fully understood, especially in plants having symbotic relat...
2018-07-27 | MTBLS481 | MetaboLights
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053334 |
ProteomicsProteomic and transcriptome analysis of DIA protein in Morchella edulis
In proteomics, DIA technology, as a high-throughput and high-sensitivity protein detection technique, can comprehensively and accurately identify and quantify proteins in samples. For morel mushrooms, DIA proteomic analysis can provide a deeper understanding of their protein composition, structure, ...
ORGANISM(S): Morchella Sextelata 
2024-11-25 | PXD058217 |
ProteomicsProteins that interaction with SCARB2 in HCCLM3 cells and analysis of acetylation site of MYC in SCARB2-overexpressing HCCLM3 cells
Quantitative mass spectrometry (MS)-based proteomics to assess acetylation modification of MYC in HCCLM3 cells with SCARB2 overexpression and analysis of SCARB2 immunoprecipitates in HCCLM3 cells.
ORGANISM(S): Homo Sapiens 
2023-08-12 | PXD044544 |
ProteomicsLRRC71 is essential for sperm motility, fertilization and male fertility
Although sperm supply half the genomic material necessary for generating viable offspring in sexual reproduction, the core molecular mechanisms underlying their formation remain largely unelucidated. Here, we demonstrate that leucine-rich repeat-containing 71 (LRRC71) is essential for spermatogenesi...
ORGANISM(S): Mus Musculus 
2026-04-29 | PXD077837 |
ProteomicsPrecipitation mediates the role of stochastic process in soil microbial community assembly
Precipitation change is often associated with climate warming, but its effects on soil microbial community assembly remain relatively underexplored. Traditionally, it is thought that increasing the magnitude of environmental changes will increase the importance of deterministic processes in communit...
ORGANISM(S): Uncultivated Soil Bacterium 
2020-12-13 | PXD023103 |
ProteomicsSpatial-temporal protein interactome profiling via condensation enhanced crosslinking
MS data for the verification of metabolic incorporation of δ-photolysine, calculation for the crosslinking distance by DegP crosslinking, and the proteomics analysis for the dynamic direct interactome of NPM1 as well as the SG-specific interactomes of SARS-CoV-2 Nucleocapsid protein and YTHDF1/2.
ORGANISM(S): Homo Sapiens Escherichia Coli Severe Acute Respiratory Syndrome Coronavirus 2 
2024-09-11 | PXD052099 |
ProteomicsIntegrated Proteogenomic Characterization of Medullary Thyroid Carcinoma
Global proteome data for 102 MTC samples, and phosphoproteome data for 74 MTC samples
ORGANISM(S): Homo Sapiens 
2022-04-01 | PXD032887 |
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