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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
UnknownA Machine Learning-Based Prediction Model for Acute Kidney Injury in Patients With Community-Acquired Pneumonia: Multicenter Validation Study.
Not available
S-EPMC11695953 | biostudies-literature
UnknownJanus adhesive bio-patches with targeted drug delivery enabled anti-bacteria and pro-angiogenesis for dura mater repair.
Not available
S-EPMC11804716 | biostudies-literature
ProteomicsJMJD2 regulates enhancer-promoter interactions via biocondensate formation
Enhancer-promoter (E-P) interactions regulate transcription for cell fate determination. However, the regulatory mechanisms of E-P interactions remain elusive. Here, a chromatin interaction-based proteomics approach, LoopID, was developed to profile the proteins at certain E-P anchors, which were te...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD069064 | Pride
Enhancer-promoter interactions Proximity ligation Loopid Biocondensates Proteome 
ProteomicsA CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation
CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.
ORGANISM(S): Homo Sapiens 
2026-03-03 | PXD075116 |
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