A CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation

ABSTRACT: CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.

ORGANISM(S): Homo Sapiens

SUBMITTER: Mian Wu  

PROVIDER: PXD075116 | iProX | Tue Mar 03 00:00:00 GMT 2026

REPOSITORIES: iProX