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TranscriptomicssRNA profiling during Oxytricha conjugation
In Oxytricha, the somatic genome is responsible for vegetative growth, while the germline contributes DNA to the next sexual generation. Somatic nuclear development eliminates all transposons and other so-called "junk DNA", which constitute ~95% of the germline. We demonstrate that Piwi-in...
ORGANISM(S): Oxytricha trifallax 
2012-09-01 | E-GEOD-40081 | biostudies-arrayexpress
TranscriptomicsOtiwi1-interacting RNAs at four time points during Oxytricha conjugation
Genome duality in ciliated protozoa offers a unique system to showcase their epigenome as a model of inheritance. In Oxytricha, the somatic genome is responsible for vegetative growth, while the germline contributes DNA to the next sexual generation. Somatic nuclear development eliminates all transp...
ORGANISM(S): Sterkiella histriomuscorum 
2012-09-01 | E-GEOD-35018 | biostudies-arrayexpress
TranscriptomicsThe menu of features that define primary microRNAs and enable de novo design of microRNA genes
MicroRNAs (miRNAs) are small regulatory RNAs processed from stem-loop regions of primary transcripts (pri-miRNAs), with the choice of stem-loops for initial processing largely determining what becomes a miRNA. To identify sequence and structural features influencing this choice, we determined cleava...
ORGANISM(S): synthetic construct 
2015-09-24 | E-GEOD-67937 | biostudies-arrayexpress
TranscriptomicsComprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by differentiation block at the promyelocyte stage. Besides the presence of chromosomal rearrangement t(15;17) leading to formation of PML-RARA fusion, other genetic alterations have also been implicated in APL. ...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-77946 | biostudies-arrayexpress
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