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TranscriptomicsNext-Generation Sequencing Identifies Differentially Expressed Genes in Embryonic Hearts Following Caffeine Treatment
Purpose: This study aimed to identify differentially expressed genes including alternative splice variants in embryonic ventricles following in utero caffeine treatment. Methods: Pregnant CD-1 mice were injected with 20 mg/kg of caffeine or vehicle control daily from embryonic day (E) 6.5-9.5. On E...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-56902 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Identifies Differentially Expressed Genes in Zebrafish Embryos and Larvae Following Benzo[a]pyrene Exposure
Purpose: This study aimed to identify differentially expressed genes and transcripts in zebrafish embryos and larvae following benzo[a]pyrene (BaP) exposure. Methods: Adult zebrafish (2 males × 4 females, N=6 replicate tanks for each treatment) were acclimated for 7 days in an 818 Low Temp Illuminat...
ORGANISM(S): Danio rerio 
2015-09-04 | E-GEOD-64198 | biostudies-arrayexpress
TranscriptomicsIn utero caffeine exposure alters DNA methylation patterns in adult hearts
Our previous research demonstrated that caffeine exposure on embryonic day (E) 8.5 increased body weight, altered cardiac morphology and function in adult male mice. However, these adverse effects were not observed in adenosine A1 receptor knockout (A1AR-/-) mice. Our hypothesis is that A1AR action ...
ORGANISM(S): Mus musculus 
2015-12-19 | E-GEOD-43030 | biostudies-arrayexpress
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