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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
UnknownMaternal circulating exosomal miR-185-5p levels as a predictive biomarker in patients with recurrent pregnancy loss.
Not available
S-EPMC10033820 | biostudies-literature
UnknownroX1 and roX2 lncRNAs promote heterochromatinization in intestinal stem cells and impair longevity
Not available
S-SCDT-10_1038-S44319-026-00791-8 | biostudies-other
Proteomicsproteomics of Type 2 Diabetes Mellitus-Induced Gastroenteropathy in the db/db Mouse Model
proteomics of Type 2 Diabetes Mellitus-Induced Gastroenteropathy in the db/db Mouse Model
ORGANISM(S): Mus Musculus 
PXD051386 |
ProteomicsComparative proteome analyses of Ophiocordyceps sinensis at different stages
In this study, using an iTRAQ quantitative approach coupled with LC-MS/MS and bioinformatics, the proteomes were analyzed for the major three stages covering the fruiting body developmental process, including sclerotium (ST), primordium (PR) and mature fruiting body (MF), with a focus on fruiting bo...
ORGANISM(S): Ophiocordyceps Sinensis 
PXD021260 |
ProteomicsMitochondrial glutamine import sustains mitochondrial translation independent of glutaminolysis in cancer
Oxidative phosphorylation (OXPHOS) fulfills energy metabolism and biosynthesis through tricarboxylic acid (TCA) cycle and an intact electron transport chain (ETC). Mitochondrial glutamine import (MGI) replenishes TCA cycle through glutaminolysis, but its broader roles in cancer remains unclear. Here...
ORGANISM(S): Homo Sapiens 
PXD069373 |
ProteomicsThe role of ptpn21 in hematopoietic stem cells
To identify the downstream substrate/effector that mediates Ptpn21 function. We applied comprehensive phosphoproteomics analysis with Lin- cells isolated from Ptpn21-/- and Ptpn21+/+ mice. The analysis revealed many pTyr sites on molecules associated with cytoskeleton. Additionally, we present a lis...
ORGANISM(S): Mus Musculus 
PXD011381 |
ProteomicsOligomerization of PRMT1 Regulated RNA-Binding Protein Cascade Promotes Pancreatic Ductal Adenocarcinoma
PRMT1 is the predominant type I protein arginine methyltransferase responsible for generating monomethylarginine and asymmetric dimethylarginine (MMA and ADMA) in various protein substrates. It regulates numerous biological processes, including RNA metabolism, mRNA splicing, DNA damage repair, and c...
ORGANISM(S): Homo Sapiens 
2025-03-12 | PXD061743 |
ProteomicsSLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth
Taurine plays a crucial role in mitochondrial tRNA modification essential for mitochondrial translation. Mammalian cells obtain taurine through plasma membrane transporter SLC6A6-mediated uptake exogenously or cytosolic biosynthesis. However, it remains unclear how taurine enters mitochondria and im...
ORGANISM(S): Homo Sapiens 
2025-11-29 | PXD071408 |
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